Pancreatic Cancer Drug Trials

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Pancreatic Cancer Clinical Trials - Mayo Clinic Research

Details: The purpose of this research study is to determine the highest safe dose of study drug that may be used when it is given together with a chemotherapy drug to patients with cancer of the pancreas. Institutional Analysis of Non-metastatic Pancreatic Adenocarcinoma Outcomes from 2011-2016 Rochester, MN new treatments for pancreatic cancer

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› Url: https://www.mayo.edu/research/clinical-trials/diseases-conditions/pancreatic-cancer Go Now

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Pancreatic Cancer: Recent Progress of Drugs in Clinical Trials

Details: Pancreatic cancer is a highly malignant tumor and one of the primary causes of cancer-related death. Because pancreatic cancer is difficult to diagnose in the early course of the disease, most patients present with advanced lesions at the time of diagnosis, and only 20% of patients are eligible for surgery. pancreatic cancer trial treatments

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› Url: https://pubmed.ncbi.nlm.nih.gov/33580411/ Go Now

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A comprehensive analysis of clinical trials in pancreatic

Details: Trials integrating conventional therapies include 84 (14%) that test novel combinations or delivery methods of established pancreatic cancer drugs, 50 (8%) trials testing FDA-approved therapies already in use for other cancer types (i.e., non-pancreatic cancer), and 54 (9%) radiation-based interventions. 23 (4%) gene therapy trials are pancreatic cancer clinical studies

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› Url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517959/ Go Now

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Pancreatic Cancer Clinical Trials - Pancreatic Cancer

Details: Pancreatic cancer clinical trials are necessary to determine whether new treatments developed in the laboratory are beneficial to people living with pancreatic cancer. The Food and Drug Administration (FDA) reviews and analyzes data from successful clinical trials to determine whether an experimental treatment should be approved for a specific pancreatic cancer studies

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› Url: https://www.pancan.org/facing-pancreatic-cancer/treatment/treatment-types/clinical-trials/ Go Now

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Pancreatic Cancer Clinical Trials - WebMD

Details: Through pancreatic cancer clinical trials, researchers test the effects of new drugs on a group of volunteers with pancreatic cancer. Following a strict protocol and using carefully controlled pancreatic clinical trials

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› Url: https://www.webmd.com/cancer/pancreatic-cancer/pancreatic-cancer-clinical-trials Go Now

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New drug combo shows early potential for treating

Details: Drugs that block PD-L1 or PD-1, also called checkpoint inhibitors, have been approved to treat cancers such as melanoma and lung cancer, but they have very little effect on pancreatic tumors. Some researchers had hypothesized that this failure could be due to the possibility that pancreatic tumors don’t express as many cancerous proteins new drug for pancreatic cancer

› Verified 8 days ago

› Url: https://news.mit.edu/2021/pancreatic-cancer-immunotherapy-cd155-0805 Go Now

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Drug Combo Shows Early Potential for Pancreatic Cancer

Details: The new therapy, which is a combination of three drugs that help boost the body's own immune defenses against tumors, is expected to enter clinical trials later this year. “We don't have a lot of good options for treating pancreatic cancer. clinical trial for pancreatic cancer

› Verified 5 days ago

› Url: https://journals.lww.com/oncology-times/Fulltext/2021/09050/Drug_Combo_Shows_Early_Potential_for_Pancreatic.13.aspx Go Now

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Advances in Pancreatic Cancer Research - National Cancer

Details: Advances in Pancreatic Cancer Research. Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). NCI-funded researchers are working to advance our understanding of how to prevent, detect, and treat pancreatic cancer. The disease is very hard to detect early and currently there is no screening test available.

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› Url: https://www.cancer.gov/types/pancreatic/research Go Now

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New drug shows encouraging survival in pancreatic …

Details: A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers. The trial looked at AZD1775, …

› Verified 2 days ago

› Url: https://www.sciencedaily.com/releases/2019/08/190814113934.htm Go Now

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Pancreas Cancer Clinical Trials & Research Studies NYU

Details: 14 "Pancreas" clinical trials found. A Randomized Phase 2 Study of Losartan and Nivolumab in Combination with FOLFIRINOX and SBRT in Localized Pancreatic Cancer (Stand up to Cancer) This multi-center, open-label, rando ized Phase II study will evaluate the effectiveness of the addition of the angiotension II type receptor blocker Losartan, or

› Verified 6 days ago

› Url: https://clinicaltrials.med.nyu.edu/cancer/clinicaltrials/?keyword=Pancreas&dmg=1&tb=tx&start=1 Go Now

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Pancreatic Cancer Clinical Trials & Research Memorial

Details: Pancreatic Cancer Clinical Trials & Research. At Memorial Sloan Kettering, our mission has always been a singular one: to care for and cure people with cancer. As part of this goal, we’ve worked for decades to find new options for people with pancreatic cancer who are not helped by the usual treatments. Many of our innovations and approaches

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› Url: https://www.mskcc.org/cancer-care/types/pancreatic/clinical-trials Go Now

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Treatment of advanced pancreatic cancer with opioid growth

Details: Opioid growth factor (OGF) is an endogenous pentapeptide that inhibits growth of human pancreatic cancer cells in culture, as well as xenografts in nude mice. To establish the maximum tolerated dose (MTD), and determine safety and toxicity of OGF, a phase I trial was performed in patients with advan …

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› Url: https://pubmed.ncbi.nlm.nih.gov/15014352/ Go Now

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The Effect of Cannabis in Pancreatic Cancer - Full Text

Details: Brief Summary: The prevalence of malnutrition is overwhelming in pancreatic cancer patients, >80% experience a weight loss >10% of their habitual weight, which may develop into cancer cachexia. Cachexia may cause decreased quality of life, increased mortality and morbidity e.g. poorer response to antitumor treatment, longer length of stay

› Verified 7 days ago

› Url: https://clinicaltrials.gov/ct2/show/NCT03245658 Go Now

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National Cancer Institute

Details: Clinical Trials; Cancer Drugs; Complementary & Alternative Medicine; Coronavirus and Cancer; Coping. Feelings & Cancer; Adjusting to Cancer; Self Image & Sexuality; Day to Day Life; Survivorship; Support for Caregivers; Questions to Ask About Cancer; Advanced Cancer. Choices For Care; Talking About Advanced Cancer; Coping With Your Feelings

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› Url: https://www.cancer.gov/about-cancer/treatment/clinical-trials/disease/pancreatic-cancer/treatment Go Now

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Pancreatic Cancer Arcus Clinical Trials Enrolling Now

Details: Pancreatic Adenocarcinoma (ARC-8) A Phase 1 open-label, dose-escalation trial to evaluate the safety, tolerability, PD, PK, and clinical activity of quemliclustat in combination with zimberelimab, nab-paclitaxel and gemcitabine in participants with advanced pancreatic cancer. Prior adjuvant therapy (including chemotherapy and/or radiotherapy

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› Url: https://arcusbio.com/clinical-trials/pancreatic-cancer/ Go Now

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Pancreatic Cancer Clinical Trials – Pancreatica.org

Details: Cancer clinical trials are, ideally, a part of a system in which a series of scientifically-controlled experiments shepherd a plausible for pancreatic cancer. New drugs, other treatments, and their combinations, including combinations of surgery, chemotherapy, targeted therapy, and …

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› Url: https://pancreatica.org/pancreatic-cancer/pancreatic-cancer-clinical-trials/ Go Now

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Clinical trials - Pancreatic Cancer UK

Details: Clinical trials for pancreatic cancer may include: finding ways to diagnose pancreatic cancer at an earlier stage. finding better ways of giving existing treatments – for example, combining different chemotherapy drugs or giving combinations in different ways. testing new treatments. looking at ways to control the side effects of treatments.

› Verified 4 days ago

› Url: https://www.pancreaticcancer.org.uk/information/clinical-trials/ Go Now

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New pancreatic cancer research gives Gilbert oncologist

Details: A new drug has been shown to fight, and in some cases, cure pancreatic cancer in animals. "In this study from Georgetown Lombardi [Comprehensive] Cancer Center in …

› Verified 8 days ago

› Url: https://www.azfamily.com/news/health/new-pancreatic-cancer-research-gives-oncologist-hope-for-patients/article_027b8974-4803-11ec-98a5-6bb82aef9f2c.html?block_id=667537 Go Now

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New Pancreatic Cancer Drug Shows Promise in Clinical Trial

Details: A new drug designed to treat pancreatic cancer has recently shown promise in clinical research, as per researchers from the University of Michigan Rogel Cancer Center. This phase 1 clinical trial tested the efficacy of AZD1775, an inhibitor of the Wee1 enzyme. This enzyme plays a key role in repairing damaged DNA.

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› Url: https://www.docwirenews.com/docwire-pick/new-pancreatic-cancer-drug-shows-promise-in-clinical-trial/ Go Now

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FDA Grants Orphan Drug Designation to LYT-200 for

Details: The FDA has granted an orphan drug designation to LYT-200, a fully human IgG4 monoclonal antibody targeting galectin-9, for use as a potential therapeutic option for patients with pancreatic cancer. 1 Galectin-9 serves as a key regulator of the immune response to cancer and may work in concert with PD-1 which alone can be targeted to improve the immune systems response to …

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› Url: https://news.cancerconnect.com/pancreatic-cancer/pancreatic-cancer-lyt-200-cholangiocarc Go Now

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Therapeutic Targeting of Autophagy in Pancreatic Ductal

Details: The mitochondrial stress signals the integrated tress response leading to cell death and also inhibits autophagy in pancreatic cancer (Ferrarini, 2021). As efforts are underway to bring ONC212 to clinical trials, we have been exploring combinations with ONC212 in …

› Verified 7 days ago

› Url: https://www.frontiersin.org/articles/10.3389/fphar.2021.751568/full Go Now

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Testing a Combination for Metastatic Pancreatic Cancer

Details: A combination including an investigational drug is being tested in pancreatic cancer that has spread beyond the pancreas or has not responded to prior chemotherapy treatment. This phase I trial will study the side effects of the new drug when given …

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› Url: https://letswinpc.org/clinical-trials/2021/09/07/combination-including-immunotherapy-for-metastatic-pancreatic-cancer/ Go Now

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Phase III Pancreatic Trial - Rafael Pharmaceuticals

Details: Phase III Pancreatic Cancer Trial Rafael Pharmaceuticals has Initiated a Phase III Trial (AVENGER 500) of CPI-613® (devimistat) in Combination with Modified FOLFIRINOX as First Line Treatment for Patients with Metastatic Pancreatic Cancer More information on the trial is available at www.clinicaltrials.gov (NCT03504423). Rafael Pharmaceuticals, Inc. has initiated a Phase III …

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› Url: https://rafaelpharma.com/clinical-trial-enrollment/phase-iii-pancreatic-trial Go Now

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pancreatic cancer: how disease burden can stymie trial

Details: EOR: Pancreatic cancer patients are very sick. They are also already very sick at the time of trial enrolment. And so, to recruit them in trials in a timely way can be a challenge. In fact, at the time of presentation, there are a lot of considerations to look at like pain, loss of appetite, weight loss, sometimes bleeding, and blood sugar issues.

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› Url: https://www.clinicaltrialsarena.com/analysis/eileen-oreilly-how-pancreatic-cancer-disease-burden-can-stymie-enrolment-momentum/ Go Now

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Investigational Therapy Targeting Pancreatic Cancer

Details: Recently, the U.S. Food and Drug Administration (FDA) granted orphan drug designation to an investigational therapy called LYT-200 for the treatment of patients with one of the deadliest forms of cancerpancreatic cancer. LYT-200 is currently under investigation in a Phase 1/2 clinical trial for treating pancreatic cancer as well as other

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› Url: https://trialsitenews.com/investigational-therapy-targeting-pancreatic-cancer-awarded-orphan-drug-status-by-fda/ Go Now

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Pancreatic Cancer Pipeline Review A Drug Pipeline

Details: Orphan drug status was granted to eryaspase by the FDA and the European Medicines Agency to treat pancreatic cancer and ALL. The agent also received fast …

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› Url: https://www.globenewswire.com/news-release/2021/10/29/2323327/0/en/Pancreatic-Cancer-Pipeline-Review-A-Drug-Pipeline-Analysis-Report-2021-DelveInsight.html Go Now

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Some pancreatic cancer clinical trial eligibility criteria

Details: A simulated pancreatic cancer clinical trial screening process showed that Black patients were significantly more likely than white patients to be excluded from clinical trials for a wide range of

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› Url: https://medicalxpress.com/news/2021-10-pancreatic-cancer-clinical-trial-eligibility.html Go Now

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Experimental drug boosts immunotherapy effectiveness in

Details: An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells …

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› Url: https://medicalxpress.com/news/2021-11-experimental-drug-boosts-immunotherapy-effectiveness.html Go Now

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Experimental Drug Boosts Immunotherapy Effectiveness in

Details: Posted in News Release Tagged cancer, immunotherapy, pancreatic cancer. WASHINGTON (November 4, 2021) — An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer.

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› Url: https://lombardi.georgetown.edu/news-release/experimental-drug-boosts-immunotherapy-effectiveness-in-pancreatic-cancer-in-mice/ Go Now

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A nationwide analysis of pancreatic cancer trial

Details: Our primary objective was to detail clinical trial participation among patients with pancreatic adenocarcinoma. Our secondary objective was to evaluate survival. Methods: We queried the National Cancer Database (2004–2016) for patients with pancreatic adenocarcinoma. Patients were stratified by trial participation: clinical trial or non-trial.

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› Url: https://www.docwirenews.com/abstracts/a-nationwide-analysis-of-pancreatic-cancer-trial-enrollment-reveals-disparities-and-participation-problems-2/ Go Now

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Rafael Pharmaceuticals Provides Update on Pivotal Phase 3

Details: The U.S. Food and Drug Administration (FDA) has given Rafael approval to initiate pivotal Phase 3 clinical trials in pancreatic cancer (AVENGER 500) and acute myeloid leukemia (ARMADA 2000) and has designated devimistat as an orphan drug for the treatment of pancreatic cancer, acute myeloid leukemia, myelodysplastic syndrome, peripheral T-cell

› Verified 9 days ago

› Url: https://www.biospace.com/article/releases/rafael-pharmaceuticals-provides-update-on-pivotal-phase-3-clinical-trial-in-patients-with-metastatic-pancreatic-cancer-and-interim-analysis-of-pivotal-phase-3-clinical-trial-in-patients-with-relapsed-or-refractory-acute-myeloid-leukemia/ Go Now

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New drug offers hope for pancreatic cancer patients

Details: Prof Wang, a world-renowned cancer researcher, is now hoping to recruit pancreatic cancer patients for a clinical trial of the drug. The University has …

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› Url: https://www.newswise.com/articles/new-drug-offers-hope-for-pancreatic-cancer-patients Go Now

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Can mRNA Vaccines Fight Pancreatic Cancer? MSK Clinical

Details: Vinod Balachandran a physician-scientist affiliated with the David M. Rubenstein Center for Pancreatic Cancer Research and a member of the Human Oncology and Pathogenesis Program and the Parker Institute for Cancer Immunotherapy, discusses how a collaboration with BioNTech — which developed the Pfizer-BioNTech COVID-19 vaccine — has led to

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› Url: https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out Go Now

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Why Are Cases of Pancreatic Cancer Rising in - drugs.com

Details: Despite tremendous advances in cancer detection and treatment for other types of cancer, the five-year survival rate of pancreatic cancer has improved from 3% to just 10% over the past several decades, Gaddam said. Risk factors include family history. "We do have a well-defined, but a small, group of high-risk patients.

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› Url: https://www.drugs.com/news/why-cases-pancreatic-cancer-rising-young-women-101219.html Go Now

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ASX Health Stocks: Amplia eyes human trials for pancreatic

Details: Amplia targets human trials for pancreatic cancer drug Noxopharm subsidiary enters licence agreement with Hudson Insitiute of Medical Research $7.2 million placement and $2 million SPP launched by Pharmaxis to support next phase of clinical trials

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› Url: https://stockhead.com.au/health/asx-health-stocks-amplia-eyes-human-trials-for-pancreatic-cancer-drug/ Go Now

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Testing the Addition of an Anti-cancer Drug, BAY 1895344

Details: This phase I trial investigates the side effects and best dose of BAY 1895344 when given together with usual chemotherapy (irinotecan or topotecan) in treating patients with solid tumors that have spread to other places in the body (advanced), with a specific focus on small cell lung cancer, poorly differentiated neuroendocrine cancer, and pancreatic cancer.

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› Url: https://www.clinicaltrials.gov/ct2/show/NCT04514497 Go Now

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Research and clinical trials for pancreatic neuroendocrine

Details: Doctors think that lenvatinib might stop the cancer from growing. Other targeted drugs that are being looked at in clinical trials include: axitinib. surufatinib. cabozantinib. pazopanib. Chemotherapy is a possible treatment for pancreatic NETs. Two chemotherapy drugs often used are streptozocin and fluorouracil.

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› Url: https://www.cancerresearchuk.org/about-cancer/neuroendocrine-tumours-nets/pancreatic-nets/research-clinical-trials Go Now

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Clinical Trial Finder Australian Pancreatic Cancer

Details: Number of listed Pancreatic Cancer Trials: 165 (as of 2020) Benefits of clinical trials . Clinical trials contribute to knowledge and progress towards treating cancer. For many patients, clinical trials may be a potential option to access experimental and cutting edge therapy. If a new treatment proves effective in a study, it may become a new

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› Url: https://www.pancreaticcancer.net.au/patients-pancreatic-cancer/clinical-trial-finder/ Go Now

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Pancreatic Cancer: Why preclinical data is key in human

Details: This disease has a high bar of success in terms of identifying a treatment that has improved benefit compared to standard of care. In about 75–100 randomized trials, we can count on one hand the number of trials that have been positive. In some people’s opinion, pancreatic cancer is a low bar because there aren’t many therapies available.

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› Url: https://www.clinicaltrialsarena.com/analysis/eileen-oreilly-why-pancreatic-cancer-preclinical-data-is-pivotal-in-trial-design/ Go Now

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New drug offers hope for pancreatic cancer patients - News

Details: Prof Wang, a world-renowned cancer researcher, is now hoping to recruit pancreatic cancer patients for a clinical trial of the drug. The University has launched a matched-funds campaign to seek support for the trial. Both these cancers share an insidious reputation for being two of the hardest to treat, with low survival rates and late diagnosis.

› Verified 4 days ago

› Url: https://www.unisa.edu.au/media-centre/Releases/2021/new-drug-offers-hope-for-pancreatic-cancer-patients/ Go Now

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Erytech Pharma Shares Fall After 'Disappointing

Details: Erytech Pharma Shares Fall After 'Disappointing' Pancreatic-Cancer Trial Published: Oct. 25, 2021 at 6:33 a.m. ET

› Verified 7 days ago

› Url: https://www.marketwatch.com/story/erytech-pharma-shares-fall-after-disappointing-pancreatic-cancer-trial-271635158039 Go Now

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Experimental drug boosts immunotherapy efficacy for

Details: According to the team, the microenvironment surrounding most pancreatic tumours is very effective at blocking immune system attacks. They therefore turned to BXCL701, an experimental oral DPP inhibitor and drug candidate that has been observed to help boost the effectiveness of immunotherapies in some early-phase clinical trials.

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› Url: https://www.drugtargetreview.com/news/99218/experimental-drug-boosts-immunotherapy-efficacy-for-pancreatic-cancer/ Go Now

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2000 to 2018 Saw Increase in Incidence of Pancreatic Cancer

Details: All News; Consumer; Pro; New Drugs; Pipeline; Clinical Trials; FDA Alerts; 2000 to 2018 Saw Increase in Incidence of Pancreatic Cancer. TUESDAY, Oct. 26, 2021 -- The incidence of pancreatic cancer increased among men and women from 2000 to 2018, with a greater relative increase among women aged younger than 55 years, according to a research letter published online Oct. 24 in the Journal of …

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› Url: https://www.drugs.com/news/2000-2018-saw-increase-incidence-pancreatic-cancer-101265.html Go Now

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