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Details: Drugs Used in Alcohol Dependence: Acarbose: 645.608 C 25 H 43 NO 18: An alpha-glucosidase inhibitor used in adjunctly with diet and exercise for the management of glycemic control in patients with type 2 diabetes mellitus. Glycoside Hydrolase Inhibitors / Trisaccharides: Acebutolol: 336.4259 C 18 …

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DrugBank Online Database for Drug and Drug Target Info

Details: DrugBank Online is offered to the public as a free-to-access resource. Use and re-distribution of the content of DrugBank Online or the DrugBank Data, in whole or in part, for any purpose requires a license. Academic users may apply for a free license for certain use …

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Drug Interaction Checker DrugBank Online

Details: Drugs may interact with each other to cause side effects that are unexpected or more severe than anticipated. Drugs may also interact and oppose the effects of one another, leading to one (or both) medications not having their intended effect. Interactions can …

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Narrow Therapeutic Index Drugs DrugBank Online

Details: Name Narrow Therapeutic Index Drugs Accession Number DBCAT003972 Description. Narrow therapeutic index (NTI) drugs are defined as those drugs where small differences in dose or blood concentration may lead to dose and blood concentration dependent, serious therapeutic failures or adverse drug reactions.

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Phenol: Uses, Interactions, Mechanism of Action DrugBank

Details: Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis.

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Aspirin: Uses, Interactions, Mechanism of Action

Details: If acetylsalicylic acid containing drugs are ingested by a patient attempting to conceive, or during the first and second trimester of pregnancy, the lowest possible dose at the shortest possible duration should be taken Label. This drug is contraindicated in the 3rd trimester of pregnancy Label.

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Nitroglycerin: Uses, Interactions, Mechanism of Action

Details: Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure. 12, 13 It was first approved in 2000 and is currently marketed by Pfizer, and other companies, depending on the dosage form. 12, 15 Nitroglycerin is available in various forms, including a spray form, sublingual tablet form, intravenous form

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Rivastigmine: Uses, Interactions, Mechanism of Action

Details: Pharmacodynamics. Rivastigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. An early pathophysiological feature of Alzheimer's disease that is associated with memory loss and cognitive deficits is a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus.

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Polyethylene glycol 400: Uses, Interactions, Mechanism of

Details: Polyethylene glycol 400 (PEG 400) is a low-molecular-weight grade of polyethylene glycol with a low-level toxicity. It is very hydrophilic, which renders it a useful ingredient in drug formulations to augment the solubility and bioavailability of weakly water-soluble drugs. It is …

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PF-07321332: Uses, Interactions, Mechanism of Action

Details: PF-07321332, by Pfizer, is an orally bioavailable 3C-like protease (3CL PRO) inhibitor that is the subject of clinical trial NCT04756531. 4 This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 4, 5 3CL PRO is responsible for cleaving

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Polyethylene glycol: Uses, Interactions, Mechanism of

Details: Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage. 2, 3 PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule. 2 Molecular weights of PEGs vary by time of the

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Ubidecarenone: Uses, Interactions, Mechanism of Action

Details: Easily compare up to 40 drugs with our drug interaction checker. Get severity rating, description, and management advice. Learn more . Drug created at October 28, 2015 15:41 / Updated at November 25, 2021 11:38 . Product Image

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Ustekinumab: Uses, Interactions, Mechanism of Action

Details: Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin (IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. 2 It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. 2 It is a targeted biologic disease-modifying anti

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Safinamide: Uses, Interactions, Mechanism of Action

Details: Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. doi: 10.1517/13543784.17.7.1115 . [ Article ] Stocchi F, Vacca L, Grassini P, De Pandis MF, Battaglia G, Cattaneo C, Fariello RG: Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition.

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Carbocisteine: Uses, Interactions, Mechanism of Action

Details: Carbocisteine is indicated over the counter and in prescription formulas to clear airway secretions in conditions associated with increased mucus. 19, 20, 21. Reduce drug development failure rates. Build, train, & validate machine-learning models. with evidence-based and structured datasets.

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Xanthine: Uses, Interactions, Mechanism of Action

Details: Xanthine. DrugBank Accession Number. DB02134. Background. A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine.

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Thymol: Uses, Interactions, Mechanism of Action DrugBank

Details: Thymol. DrugBank Accession Number. DB02513. Background. A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed) Type.

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Oliceridine: Uses, Interactions, Mechanism of Action

Details: Oliceridine is a biased opioid agonist indicated for the management of severe acute pain in adult patients. Through preferential activation of G-protein-coupled signalling pathways, oliceridine provides analgesic effect with a comparable or improved safety profile over conventional opioid agonists.

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Aprepitant: Uses, Interactions, Mechanism of Action

Details: Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of

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Chymotrypsin: Uses, Interactions, Mechanism of Action

Details: Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in

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Trastuzumab: Uses, Interactions, Mechanism of Action

Details: Generic Name Trastuzumab DrugBank Accession Number DB00072 Background. Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody 6 that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). 12 It is used as a treatment of human epidermal …

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Sulfamethazine: Uses, Interactions, Mechanism of Action

Details: Identification Summary. Sulfamethazine is an antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.. Generic Name Sulfamethazine DrugBank Accession Number DB01582 Background. A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.

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Piperazine: Uses, Interactions, Mechanism of Action

Details: Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines. Mechanism of action. Piperazine is a GABA receptor agonist.

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Meperidine: Uses, Interactions, Mechanism of Action

Details: Meperidine is an opioid agonist with analgesic and sedative properties used to manage severe pain.

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Ursodeoxycholic acid: Uses, Interactions, Mechanism of

Details: Ursodeoxycholic acid is a bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.

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Ginseng: Uses, Interactions, Mechanism of Action

Details: Identification Summary. Ginseng is a herbal supplement used in many health products.. Generic Name Ginseng DrugBank Accession Number DB01404 Background. Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties.

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Midazolam: Uses, Interactions, Mechanism of Action

Details: Generic Name Midazolam DrugBank Accession Number DB00683 Background. Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. 6 It belongs to a class of drugs called benzodiazepines.This drug is unique from others in this class due to its rapid onset of effects and short duration of action. 6 Midazolam is

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Urea: Uses, Interactions, Mechanism of Action DrugBank

Details: Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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Neostigmine: Uses, Interactions, Mechanism of Action

Details: Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier. By inhibiting acetylcholinesterase, more acetylcholine is available in the synapse, therefore, more of

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Aztreonam: Uses, Interactions, Mechanism of Action

Details: Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Poirel L, Brinas L, Fortineau N, Nordmann P: Integron-encoded GES-type extended-spectrum beta-lactamase with increased …

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Gelatin: Uses, Interactions, Mechanism of Action

Details: Gelatin is used for weight loss and for treating osteoarthritis, rheumatoid arthritis, and brittle bones (osteoporosis). Some people also use it for strengthening bones, joints, and fingernails. Gelatin is also used for improving hair condition and to shorten the recovery after exercise and sports-related injury 15.

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Gliclazide: Uses, Interactions, Mechanism of Action

Details: Gliclazide is a sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Brand Names. Diamicron. Generic Name. Gliclazide. DrugBank Accession Number. DB01120. Background. Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

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Favipiravir: Uses, Interactions, Mechanism of Action

Details: Identification Summary. Favipiravir is an antiviral used to manage influenza, and that has the potential to target other viral infections.. Generic Name Favipiravir DrugBank Accession Number DB12466 Background. Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. 7,9 The

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Permethrin: Uses, Interactions, Mechanism of Action

Details: Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. Mechanism of action. Permethrin acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated.

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Deslanoside: Uses, Interactions, Mechanism of Action

Details: Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Mechanism of action. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and

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Digoxin: Uses, Interactions, Mechanism of Action

Details: Generic Name Digoxin DrugBank Accession Number DB00390 Background. Digoxin is one of the oldest cardiovascular medications used today. 5 It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. 7 Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. 25 This drug originates from the foxglove plant, also known as the

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Glutathione: Uses, Interactions, Mechanism of Action

Details: Identification Generic Name Glutathione DrugBank Accession Number DB00143 Background. A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

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Baclofen: Uses, Interactions, Mechanism of Action

Details: Because many drugs are excreted in human milk, caution is warranted when baclofen is administered to a nursing woman Label. Pathways Not Available Pharmacogenomic Effects/ADRs . Not Available Interactions Drug Interactions . This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing

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Lopinavir: Uses, Interactions, Mechanism of Action

Details: Generic Name Lopinavir DrugBank Accession Number DB01601 Background. Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. 7 Lopinavir is marketed and administered exclusively in combination with ritonavir - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to

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Crizotinib: Uses, Interactions, Mechanism of Action

Details: Crizotinib is a receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase …

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Milrinone: Uses, Interactions, Mechanism of Action

Details: Pharmacodynamics. Milrinone is a bipyridine derivative with positive inotropic and lusitropic effects that also results in peripheral vasodilation with minimal chronotropic effects over a therapeutic range of 100 to 300 ng/mL. 8,6 As such, milrinone is used in decompensated congestive heart failure. 8 Studies have demonstrated that milrinone exhibits sigmoidal effects, such that increasing

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Magnesium: Uses, Interactions, Mechanism of Action

Details: Generic Name Magnesium DrugBank Accession Number DB14513 Background. Magnesium is classified as an alkaline earth metal and has 2 hydration shells. 1 The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. 1 Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, …

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Mineral oil: Uses, Interactions, Mechanism of Action

Details: Mechanism of action. Mineral oil sits on the surface of the skin and in spaces between cells and provides a hydrophobic barrier 2. This barrier prevents trans-epidermal water loss to trap water in the skin. Overall this leads to greater hydration, flexibility, and softness of the stratum corneum. Absorption.

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Calcium: Uses, Interactions, Mechanism of Action

Details: Identification Summary. Calcium is a mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.. Generic Name Calcium DrugBank Accession Number DB01373 Background. Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal

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Peramivir: Uses, Interactions, Mechanism of Action

Details: Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. Being an influenza virus neuraminidase inhibitor, peramivir works by preventing new

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Valganciclovir: Uses, Interactions, Mechanism of Action

Details: Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. Type.

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Cinacalcet: Uses, Interactions, Mechanism of Action

Details: Pharmacodynamics. Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues). Secondary hyperparathyroidism (HPT) in patients with chronic kidney disease (CKD) is a progressive disease, associated with increases in parathyroid hormone (PTH) levels and derangements in calcium and phosphorus metabolism.

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Isoniazid: Uses, Interactions, Mechanism of Action

Details: Isoniazid is an antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.

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