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A Guide to New Diabetes Drugs

Details: A Guide to New Diabetes Drugs. New medicines for people who have diabetes seem to pop up all the time: drugs that help the body break down carbohydrates, drugs that increase excretion of glucose in the urine, drugs that help muscles respond to insulin and drugs that stimulate the pancreas to produce it … the list of pharmaceutical options to

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Drug Abuse and Addiction Research at Johns Hopkins

Details: Taking drugs creates memories of objects, places or people that users associate with doing drugs, which triggers cravings and drug-seeking behavior when the user re-encounters those situations. Several IBBS neuroscientists study these molecular changes as …

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Dopamine Drugs and Possible Side Effects The Johns

Details: Dopamine Drugs and Possible Side Effects. Levodopa and the dopamine agonists (e.g., ropinirole, pramipexole, rotigotine), though proven to be very effective agents for managing RLS, may lead to the development of three common problems when used chronically: augmentation, compulsive behavior and sleepiness. These three problems will not occur in

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Substance Abuse / Chemical Dependency Johns Hopkins …

Details: Substance (drug) abuse (alcohol or other drugs) Substance abuse is the medical term used to describe a pattern of using a substance (drug) that causes significant problems or distress. This may be missing work or school, using the substance in dangerous situations, such as driving a car.

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Drug Rashes Johns Hopkins Medicine

Details: 8 rows · Drug rashes are the body's reaction to a certain medicine. The type of rash that happens …

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New Index Explains Why Some Drugs Work Better than …

Details: Shen points out that drugs with lower indices, close to 1, such as the nucleoside reverse transcriptase inhibitor AZT (at 1.23), are known to work when matched with more powerful drugs, such as the non-nucleoside reverse transcriptase inhibitor efavirenz, at 5.72.

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Help for Managing Multiple Medications Johns Hopkins

Details: If dealing with multiple medications is a daily challenge for you or a loved one, you’re not alone. Nearly 40 percent of older adults take five or more prescription drugs. The best approach: “When you’re using several medications, be proactive,” says Jessica Merrey, PharmD, clinical pharmacy

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New Cancer Immunotherapy Drugs Linked To Arthritis in …

Details: Case reports on 13 cancer patients suggest that a small number of cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at some higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory arthritis, according to a preliminary study by Johns Hopkins Medicine researchers.

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Herbal Medicine Johns Hopkins Medicine

Details: Many prescription drugs and over-the-counter medicines are also made from plant products, but these products contain only purified ingredients and are regulated by the FDA. Herbal supplements may contain entire plants or plant parts. Herbal supplements come in all forms: dried, chopped, powdered, capsule, or liquid, and can be used in various

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Johns Hopkins Health System and Office of Injection …

Details: Infusions may be concurrent (i.e., multiple drugs are infused simultaneously through the same line) or sequential (infusion of drugs one after another through the same access site). NOTE: IV infusion differs from an IV push which is defined as an infusion lasting 15 minutes or less.

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What Are Opioids

Details: What Are Opioids? Opioids are a class of drugs naturally found in the opium poppy plant and that work in the brain to produce a variety of effects, including the relief of pain with many of these drugs. Opioids can be prescription medications often referred to as painkillers, or …

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Scientists Reprogram Cancer Cells with Epigenetic Drugs

Details: The drugs, azacitidine (AZA) and decitabine (DAC), are epigenetic-targeted drugs and work to correct cancer-causing alterations that modify DNA. The researchers said the drugs also were found to take aim at a small but dangerous subpopulation of self-renewing cells, sometimes referred to as cancer stem cells, which evade most cancer drugs and

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Medicines and the Digestive System Johns Hopkins Medicine

Details: Medicines and the Digestive System. Medicines taken by mouth can affect the digestive system in a number of different ways. Both prescription and over-the-counter medicines, while usually safe and effective, may create harmful effects in some people. Certain medicines taken together may interact and cause harmful side effects.

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Food-Drug Interactions Johns Hopkins Medicine

Details: Food-medicine interactions can happen with both prescription and over-the-counter (OTC) medicines. These include antacids, vitamins, iron pills, herbs, supplements, and beverages. Some nutrients can affect the way you metabolize certain medicines by binding with the medicine's ingredients. This reduces their absorption or speeds their elimination.

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Some Anti-Inflammatory Drugs Affect More Than Their

Details: Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved doses and/or for long periods of time, these prescription-level NSAIDs and other drugs that affect the membrane may produce wide-ranging and unwanted side effects.

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Anesthesia Johns Hopkins Medicine

Details: Use of street drugs (such as marijuana, cocaine, or amphetamines). People are often reluctant to disclose the use of illegal drug, but you should remember that all conversations between you and your surgeon and anesthesiologist are confidential. It is crucial that he or she know about your past, recent, and current use of these substances, as

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How Statin Drugs Protect the Heart Johns Hopkins Medicine

Details: For most people, the answer is a resounding yes, according to a 2014 Johns Hopkins meta-analysis of 20 years worth of published research. It showed that the risks of long-term use of statin drugs are low and the potential benefits are very high. Researchers combed through hundreds of papers that had studied statins since 1994 to determine the

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Angiogenesis Inhibitors Johns Hopkins Medicine

Details: Some other cancer drugs are known to act in similar ways. Thalidomide and lenalidomide have been identified as having mild activity as angiogenesis inhibitors. An angiogenesis inhibitor medicine, bevacizumab, has been approved by the FDA to aid in the treatment of glioblastoma, colorectal cancer, non-small cell lung cancer, liver

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Heart Medications: The Power of a Team Approach Johns

Details: These medications lower your blood pressure by relaxing your blood vessels. Beta-blockers. Using these drugs lowers your heart rate and causes your heart to beat less forcefully. Diuretics. These encourage your kidneys to drain more water and salt from your system, which lowers the volume of blood that your heart has to pump through your vessels.

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Experimental Drug Stops Parkinson’s Disease Progression in

Details: Similar drugs to NLY01 already approved by the Food and Drug Administration for the treatment of type 2 diabetes include exenatide, lixisenatide, liraglutide and dulaglutide, each of which can cost approximately $2,000 for a 90-day supply. NLY01 is a long-acting drug with improved the brain penetration compared to these approved drugs for diabetes.

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Nuclear Medicine Johns Hopkins Medicine

Details: Nuclear medicine is a specialized area of radiology that uses very small amounts of radioactive materials to examine organ function and structure. This branch of radiology is often used to help diagnose and treat abnormalities very early in the progression of a disease, such as thyroid cancer.

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Gastroesophageal Reflux Disease (GERD) Treatment Johns

Details: These drugs are somewhat less effective than PPIs. Your doctor may prescribe them in combination with an acid-suppressing drug. TIF and Other Endoscopic Therapy. Transoral incisionless fundoplication (TIF) is an option to address GERD. TIF can mean a shorter treatment time, less pain and faster recovery compared to laparoscopic surgery.

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Epigenetics and Combining Drugs: Johns Hopkins Kimmel

Details: Whatever drug or drugs clinical trialists could get their hands on were being studied. Cynthia Zahnow was gathering the evidence and the data. Collaborating with other Kimmel Cancer Center experts, they had 70 cell lines from breast, colon, ovary, and lung cancers as well as patient biopsies that they were comparing to the cell lines.

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Chemical Cardioversion Johns Hopkins Medicine

Details: Cardioversion is a procedure used to return an abnormal heartbeat to a normal rhythm. This procedure is used when the heart is beating very fast or irregular. This is called an arrhythmia. In chemical cardioversion, medicines are used to get the heart back to a normal rhythm. It is different from

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Injectable Corticosteroids Johns Hopkins Medicine

Details: Corticosteroids are potent drugs used to reduce inflammation in the body's tissues. They are different from anabolic steroids. These are illegally used by some athletes to increase muscle tone. Corticosteroids can come in several forms: pills, liquids, creams, ointments, medicines sprayed into the

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Diabetes Medications That Treat Heart Disease, Too Johns

Details: While these medications aren’t new, the discovery that certain diabetes drugs can thwart heart disease is a recent development. Heart-Healthy Discovery. In 2008, the Food and Drug Administration (FDA) required glucose-lowering diabetes drugs to undergo testing …

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Drug-Induced Hepatitis Johns Hopkins Medicine

Details: Drug-induced hepatitis is a redness and swelling (inflammation) of the liver. It is a rare condition caused by harmful (toxic) amounts of certain medicines, vitamins, herbal remedies, or food supplements. In most cases, you may be taking a medicine for several months before it …

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Two-Drug Combination Accelerates Wound Healing And Reduces

Details: A combination of two drugs already approved by the U.S. Food and Drug Administration for different applications reduces wound healing time by one-quarter and significantly decreases scar tissue in mice and rats, Johns Hopkins researchers report. If the findings, reported in the September issue of the Journal of Investigative Dermatology, hold true in future human studies, the dual treatment

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More Tumor Mutations Equals Higher Success Rate With

Details: The “mutational burden,” or the number of mutations present in a tumor’s DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows. The finding, published in the Dec. 21 New England Journal of Medicine , could be used to guide future

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Osteoporosis Johns Hopkins Medicine

Details: Drugs: Estrogen Therapy (ET) and Hormone Therapy (HT) Use: Increases bone density in the spine and hip and decreases fractures at both sites. Typically used for prevention in postmenopausal women. Form: Commonly available as tablets or skin patches. Bisphosphonates. Side effects: Oral bisphosphonates can cause upper stomach issues like heartburn.

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Potassium Loss From Blood Pressure Drugs May Explain

Details: Johns Hopkins researchers have discovered that a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes. The drugs helpfully accelerate loss of fluids, but also deplete important chemicals, including potassium, so that those who take them are generally advised …

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Collagenous and Lymphocytic Colitis Treatment Johns

Details: Collagenous & Lymphocytic Colitis Treatment: Adrenocorticoids. If sulfasalazine failed to improve your symptoms after two to four weeks, or you were unable to tolerate it well, adrenocorticoids may be prescribed. Adrenocorticoid medication is a steroid treatment that can …

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Statins Likely Not Helpful in Reducing Covid-19 Mortality

Details: Recent small-sample studies (fewer than 200 patients) have suggested that statins — drugs that lower levels of low-density lipoprotein (LDL), a form of cholesterol linked to heart disease and stroke — also may reduce the chances of severe disease or death from COVID-19.

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FAQ: Shipping of investigational drugs IND and non-IND

Details: a. Investigational drugs with an Investigational New Drug (IND) may be shipped to any location within the U.S.A. b. Investigational drugs without an IND (non-IND) cannot be shipped across state lines (outside of Maryland). c. Investigational drugs (with or without an IND) cannot be shipped internationally. 2.

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Priority Partners Medical Benefit Drug Prior Authorization

Details: Preferred Drugs The following is a list of preferred drugs. Use of preferred product (s) is required prior to coverage of non-preferred product (s). Please note that both preferred and non-preferred products are subject to prior authorization.

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Anti-PD-1: A Novel Immunotherapy: Johns Hopkins Kimmel

Details: A new pipeline of immune-modulating drugs that work by similar but distinct mechanisms is now entering testing in our clinics. Read the latest news about this work. For more information: Drs. Suzanne Topalian, Julie Brahmer, Drew Pardoll and lung cancer patient David Gobin discuss anti-PD-1 and anti-PD-L1 therapy in the video “Harnessing the

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Common Vesicants

Details: Common Vesicants - Adult Patients . Medication IV Infusions Infiltrate treatment Peripheral Line Concentration Central Line Concentration Max Rate Miscellaneous Dextrose ≤ 10% 20%; 50% 0.8 g/kg/hr Hyaluronidase, Warm Applic.

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Medications and Pregnancy Johns Hopkins Medicine

Details: The risks involved with medicine use during pregnancy. When you are pregnant, always check with your healthcare provider or midwife before taking any prescription or over-the-counter medicines. This includes herbs and dietary supplements. All medicines affect the fetus. How they affect the fetus depends on the stage of development and the type

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Why Aren’t My Antidepressants Working

Details: TCA drugs increase serotonin and norepinephrine in the brain, but unlike other antidepressant types, they also block acetylcholine, a neurotransmitter associated with increased stress, anxiety and depression. You may experience more side effects with TCA medications than with SSRI or …

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Chemotherapy for Pancreatic Cancer Johns Hopkins Medicine

Details: Chemotherapy drugs are usually administered in cycles, with alternating periods of treatment and recovery. They may be given alone or in conjunction with radiation therapy or surgery. According to the American Cancer Society, the following chemotherapy drugs may be used to treat pancreatic cancer: Gemcitabine (Gemzar) 5-fluorouracil (5-FU)

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Esketamine for Treatment-Resistant Depression Johns

Details: There’s good news for people with severe treatment-resistant depression: Esketamine is a groundbreaking therapy that can provide relief from major depression within hours. “For the first time in 60 years, we have a new antidepressant therapy that isn’t just a spinoff of existing drugs,” says Adam Kaplin, M.D., Ph.D., a psychiatrist with

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Procedural Sedation Johns Hopkins Medicine

Details: Procedural sedation is a medical technique. It’s used to calm a person before a procedure. It involves giving you sedatives or pain pills. These drugs ease discomfort, pain, and anxiety. They are usually given through an IV line in your arm. Or you may swallow or inhale them. While you are under

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