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Adolescents, Drugs, and COVID-19: Special Challenges

Details: Adolescents with immunocompromised status, a significant proportion of whom are formed by adolescents who inject drugs, 11 are also at a higher risk of infection and mortality. 6. Adolescence is the age of experimentation and a sense of invincibility marked by …

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A kinder, gentler drug war

Details: Kennedy, JE, Unah, I, Wahlers, K (2018) Sharks and minnows in the war on drugs: A study of quantity, race and drug type in drug arrests. UC Davis Law Review 52(2): 729 – 800 . Google Scholar

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Prospects for new drugs to treat binge-eating disorder

Details: Both drugs have a catecholaminergic mode of action, they increase noradrenergic and dopaminergic neurotransmission in the frontal cortex (FC), increase cognitive control and reduce impulsivity in ADHD. Both drugs also stimulate the mesolimbic dopaminergic reward pathway. The differences are (i) mechanism of action, that is, d-amphetamine is a

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The art and science of drug titration

Details: For some drugs, all of these factors may be interrelated, leading to the necessity of an individualized, patient-centered approach that blends together the art and science of drug titration. This is in contrast to the population-based approach of “one-size-fits-all” dosing, which may not be as equally safe and effective among all patients.

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A Review and Assessment of Drug-Induced Thrombocytosis

Details: In all, 43 case reports of drug-induced thrombocytosis from a wide variety of drugs and drug classes were reviewed using a modified Naranjo probability scale that included criteria specific for thrombocytosis. Conclusions: Drug-induced thrombocytosis is a relatively rare adverse drug reaction. The strongest evidence of causality supports low

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Drug Interactions with Medical Plastics, 1983

Details: Knowledge about drug interactions with plastic materials used in medical and surgical practice is at an elementary stage. Information that has appeared so far on the sorption of drugs to intravenous fluid containers, delivery sets, syringes, or other plastic apparatus has highlighted that polyvinyl chloride (PVC) is the major offender in this respect.

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Alcohol, drugs, and attention-deficit/ hyperactivity

Details: Alcohol, drugs, and attention-deficit/ hyperactivity disorder: a model for the study of addictions in youth. Timothy E. Wilens and Joseph Biederman. Journal of Psychopharmacology 2006 20: 4, 580-588 Download Citation. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice

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Life in the Fast Lane: Drugs, Hedonistic Lifestyles, and

Details: Both simultaneous (within-month) relationships and effects involving a 1-month lag are examined. Offenders were more likely to engage in property crime and drug dealing during months in which they used hard drugs, marijuana, and alcohol, and when they engaged in …

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Updated List of Light-Sensitive Oral Medications

Details: In investigating this request for information, a list of light-sensitive oral prescription drug products published in Hospital Pharmacy in 2009 was identified. This discovery highlighted the need for both an updated list and one which distinguished oral solid products and oral liquid products.

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Adolescents’ perception of substance use and factors

Details: There is a growing body of evidence confirming the effectiveness of school-based substance use prevention programmes in raising awareness about the harms of illicit drugs and in reducing the prevalence of substance abuse among students. 12 However, ineffective implementation of these evidence-based programmes may hinder successful outcome. 13

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‘There is no “war on drugs”’: An investigation into county

Details: As illicit drugs increasingly fill the void of real market opportunities, the black economy becomes so normalised, as do the behaviours of those involved, that it becomes increasingly difficult to pursue those engaged in illicit drug markets. Indeed, what is becoming increasingly obvious is that the ‘war on drugs’ in its current form is

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Review of Drugs Approved via the 505(b)(2)

Details: Review of Drugs Approved via the 505(b)(2) Pathway: Uncovering Drug Development Trends and Regulatory Requirements Ingrid Freije, PharmD, MSc1,2, Ste´phane Lamouche, PhD1, and Mario Tanguay, PhD1,3 Abstract A 505(b)(2) application is a type of US new drug application (NDA) that contains full reports of investigations of safety and

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Cancer drug development: The missing links

Details: Generic drugs are same as brand-name drugs which are used in similar treatment programs for the approved indication and also at comparable dosing levels. On the other hand, biosimilar drugs possess high similarity with the FDA-approved biological agent, with no clinically meaningful differences with regard to safety, efficacy, or purity.

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The link between use of psychedelic drugs and mental

Details: drugs had two to three times higher prevalence of all mental health outcomes when not adjusting for lifetime use of other drugs. However, in the logistic regression analyses, correcting for all other types of drugs, the risk for having a mental health problem was not higher among psychedelic drugs users and the rest of the study population.

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The Role of the New “Date Rape Drugs” in Attributions

Details: In contrast, women's voluntary consumption of drugs prior to a sexual assault reduced perpetrator responsibility and blame and increased blame to the victim compared to other situations (except in some cases, voluntary drunkenness). These findings extend the limited research on date rape drugs and previous work on the influence of alcohol on

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Public policies on the use of drugs in Mexico and Latin

Details: The monetary taxes on the sale of drugs, such as taxes on tobacco, in a state where cannabis legalization could be considered a poor substitute for a war on drugs, and excise duties have been assumed to be unable to reduce drug use in comparison to prohibition, as the producers can always choose to sell illegally (Ramaekers et al, 2004).

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Effects of Drugs on Clinical Laboratory Tests

Details: effect of drugs on clinical laboratory tests is growing. One continuing concern is the point at which data should be considered obsolete and not reported. Generally, dataon analytical inter­ ferences of drugs have been deleted from the master file when references are more than 15 years old. However, for procedures that con­

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The pK Distribution of Drugs: Application to Drug Discovery

Details: drugs with an ionizable group has been estimated at 95%27 while an analysis of the 1999 World Drug Index (WDI28) showed that only 62.9% of that col-lection were ionizable between a pH of 2 and 12 29, 30. Wells also estimated that 75% of drugs are weak bases, 20% weak acids and the remainder contained non-ionics, ampholytes and alcohols 27. A

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Drug-induced QT interval prolongation: mechanisms and

Details: The list of drugs that cause QT prolongation continues to grow, and an updated list of specific drugs that prolong the QT interval can be found at www.qtdrugs.org. This review focuses on the mechanism of drug-induced QT prolongation, risk factors for TdP, culprit drugs, prevention and monitoring of prolonged drug-induced QT prolongation and

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The Relevance of Bioinformatics Applications in the

Details: This can occur at an even faster rate when the drugs approved for the treatment of other diseases and post-marketing safety surveillance data are available. 50,51 By relying on existing preclinical, pharmacokinetic, pharmacodynamic, and toxicity profiles of the drugs being repurposed, it is possible to effectively increase the rapidity of the

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Outside the outsiders: Media representations of drug use

Details: Abstract. This article is intended to highlight some key themes within the news media's reporting of drugs, drug users and drug-related crime. 1 Its aim is to focus on how the news media represent illegal drugs and drug users and their causal links with further criminal behaviour. The article proposes that news media and governmental beliefs

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REVIEW : Long-lasting Effects of Recreational Drugs of

Details: It seems clear, then, that some psychoactive drugs have the potential to produce persistent changes in CNS structure and, possibly, function. The goal of this article is to summarize current knowledge regarding the long-term effects of several popular recreational drugs, including MDMA and related amphetamine analogs, cocaine, marijuana

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Drugs & Prostitution

Details: Overall, 87% of female and 65% of male prostitutes had used drugs other than alcohol and tobacco in the last year. They used over-the-counter medicines twice as frequently as the general population but most of this overrepresentation could be attributed to vitamin pills and tonics.

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Sex, Drugs, and Genes: Illuminating the Moral Condemnation

Details: condemnation of recreational drugs, presumably because of the association between drug use and casual sex. We sought to estimate the extent to which genetic, shared environmental, and non-shared environmental effects underlie the covari-ance between condemnation of recreational drugs and sexual strategy. Results suggest that this cova-

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Knowledge, attitude, and utilization of drugs toward COVID

Details: Drugs: any chemical substance which includes modern medicines, traditional medicine, and social substances used for the prevention and or treatment of COVID-19. Traditional medicines: alternative medicines or any herbal medicine used by the community for the prophylaxis or treatment of COVID-19.

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Antiparkinsonian Drugs in the Treatment of Neuroleptic

Details: Most patients on neuroleptic therapy experience extrapyramidal symptoms in one form or another during treatment. While the risk of extrapyramidal symptoms appears diminished with the newer and “atypical” neuroleptics (for example, risperidone, remoxipride, clozapine), it is not eliminated.

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Advancements in therapeutic drugs targeting of senescence

Details: Besides, we also collected data on some drugs that have been applied in clinical trials . 6,31,43,195 –198 In addition to promote healthy aging, these drugs could also serve as the therapeutic drugs for various age-related diseases. To improve healthy aging and longevity is a big strategy for social and economic development in the world.

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Police Violence and Corruption in the Philippines: Violent

Details: The war on drugs has, we argue, radically reconfigured the parameters of these relationships and how residents may negotiate them through money, relationships, and diskarte. The first element in these reconfigured relationships is that the price of survival seems to have gone up significantly. If we compare the amounts that we registered before

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Screening for Drugs of Abuse. I: Opiates, Amphetamines and

Details: common drugs. Chloroform mixed with 10070 (v/v) isopropanol has been used to extract a range ofdrugs from a buffered sample." Commercial systems include Toxi-Tubes" (Toxi-Lab Inc., Irvine, CA, USA). Toxi-TubesA (alkaline pH) are designed to extract basic drugs such as opiates: Toxi-TubesB (acid pH) are designed to extract acidic drugs such as

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Sex, Drugs, and Genes: Illuminating the Moral Condemnation

Details: In the past five decades, the war on drugs has borne immense financial, social, and political costs and consequences. Therefore, understanding the factors that shape moral views toward recreational drug use is crucial. Recent research indicates that sexual strategy (i.e., being more vs. less open to sex outside of a committed relationship

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Compatibility of Lactated Ringer’s Injection With 94

Details: A total of 8 drugs were found to be physically incompatible. Of these incompatible drugs, 7 were directly identified visually and 1 was confirmed by the light obscuration particle count test. Conclusion: Lactated Ringer’s injection was physically compatible for 4 hours with 86 tested drugs during simulated Y-site administration. Eight drugs

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Social Stability and Unmet Health Care Needs in a

Details: Despite being a high-risk population, the health needs of women who use drugs are often unmet or overlooked which may have significant consequences. 13 Drug use among women is associated with increased barriers to healthcare. 14 Women who use drugs are at greater risk of fatal or late-stage breast cancer diagnoses, 15 and pregnant women who use

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Effects of Drugs on the Liver

Details: 1968), phosphorus and cytotoxic drugs. 77 Purine-analogues, such as 6-mercaptopurine, are known hepato-toxinsand occasionally cause intra­ hepatic cholestasis and hepatic necrosis (Einhorn and Davidsohn, 1964). These drugs may be parti­ cularly dangerous if the patient has underlying hepato-cellulardisease, for instance, active chronic hepatitis.

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Pharmacokinetic Interactions of Drugs with St John’s Wort

Details: Because the potential interaction of St John’s wort with other drugs is a major safety concern, additional systematic research on herb-drug interactions and appropriate regulation in herbal safety and efficacy is needed. Keywords . cytochrome P450, drug interactions P-glycoprotein, St John’s wort.

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Drugs, Guns, and Disadvantaged Youths: Co-Occurring

Details: Drugs, Guns, and Disadvantaged Youths: Co-Occurring Behavior and the Code of the Street Show all authors. Andrea N. Allen 1. Andrea N. Allen . University of South Carolina, Columbia See all articles by this author. Search Google Scholar for this author, Celia C. Lo 2. Celia C. Lo .

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Drug Tolerance, Drug Addiction, and Drug Anticipation

Details: Abstract. Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of

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Drugs, Incarceration, and HIV/AIDS Among African American

Details: Incarceration and HIV/AIDS disproportionately affect African American men compared to the U.S. population as a whole. Disparities in relation to crime and HIV/AIDS for Black men suggest that these phenomena have elements in common, particularly given the mediating role of illicit drug use or drug activities in both cases.

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Harms and benefits associated with psychoactive drugs

Details: Drugs that were rated as having low harms and low benefits were Viagra, hallucinogens, nitrous oxide and mild stimulants. The low beneficial rating of hallucinogens contradicts the findings of our prior UK drug survey (Morgan et al., 2010b). where hallucinogens were rated as one of the drugs with greatest long-term benefits. Hallucinogens were

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Drugs, moral panics and the dispositive

Details: The concept of ‘moral panics’ continues to be used as a framework for analysing the causes, structures and functions of social and political crises. Nonetheless, as an analytical tool, such a framework is limited in its capacity to explain the ongoing and interconnected relationships between drugs and society.

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New psychoactive substances: a review and updates

Details: New psychoactive substances (NPS) are a complex and diverse group of substances often known as either designer or synthetic drugs, or by the more popular but misleading colloquial term of ‘legal highs’. 1,2 They tend to be either analogues of existing controlled drugs and pharmaceutical products or newly synthesised chemicals, created to mimic the actions and psychoactive effects of

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Drugs, pesticides and metabolites in forensic post-mortem

Details: This study investigated the presence of illicit and prescription drugs, pesticides and metabolites in 111 post-mortem blood samples from cases investigated by the Forensic Medical Institute of the Federal District, Brazil. Quantitative analysis was performed for 14 analytes using a validated programmed temperature vaporisation-large volume

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Drug Nanoparticles: Formulating Poorly Water-Soluble …

Details: poorly water-soluble drugs, has addressed many of these major concerns and has successfully expanded the scope and use of nanoparticulates or nanosuspensions to include the oral, inhala-tion, intravenous, subcutaneous (SubQ) and intramuscular (IM), and ocular routes of delivery (Merisko-Liversidge, Liversidge, et al., 2004)

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The Normalization of Leisure Sex and Recreational Drugs

Details: The central argument in the normalization thesis is that the use of illicit drugs (particularly cannabis and, to a lesser extent, party drugs) has become increasingly tolerated by both drug users and non-drug users, leading not only to a change in drug-related behaviors (such as increased prevalence of use, frequency and recency) but also a

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A review: Mechanism of action of antiviral drugs

Details: drugs and vaccines are because of viral variation.5 One of the important ways of finding antiviral drugs is the computer based drug discovery and for this approach nelfinavir is an example discovered in the 1990s for the treatment of human immuno-deficiency virus (HIV) infection.6

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Toxicology Evaluation of Drugs Administered via Uncommon

Details: Drugs that can penetrate the blood–brain barrier (eg, midazolam) can be rapidly transported into the brain by this countercurrent transfer. Lymph pathways, perivascular spaces along the olfactory and trigeminal nerve, may act to transport molecules to the brain. As the olfactory nerves enter the nose through the cribriform plate, the nerves

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Journal of Generic Medicines: SAGE Journals

Details: Journal of Generic Medicines is the major international business journal written by and for professionals working in the generic medicines sector. It includes expert analysis, briefings and legal updates on all aspects of business development, regulatory affairs, manufacturing and marketing affecting the generic pharmaceutical industry.

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New trends in the cyber and street market of recreational

Details: European Monitoring Centre for Drugs and Drug Addiction (2004) Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. Office for Official Publications of the European Communities, Luxembourg Google Scholar

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