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New Generation of Drugs for CML MD Anderson Cancer Center

Details: New Generation of Drugs for CML. Hagop Kantarjian, M.D., presented encouraging results of a study with dasatinib for patients with chronic myeloid leukemia. Photo: John Smallwood. Although Gleevec® (imatinib) was lauded as a “smart bomb” for chronic myeloid leukemia 10 years ago, today second-line drugs — Tasigna® (nilotinib) and

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How do drugs and vaccines get FDA approval

Details: Phase II clinical trials test for safety and efficacy. Phase III studies test for efficacy and collect more safety data in a larger group of people. If a Phase III clinical trial is successful, the drug or vaccine can be submitted for FDA approval. “With cancer drugs, the approval process can take anywhere from six to 12 years,” Subbiah says.

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Teaching old drugs new tricks

Details: Drugs show accidental success in treating other conditions. Most successful cases of drug repurposing are largely serendipitous discoveries – coming more by chance than intent. Here are a few examples: Tamoxifen was originally designed to block estrogen in the hopes of preventing pregnancy.

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Managing Cancer Medication MD Anderson Cancer Center

Details: Cancer treatment usually involves taking a lot of medications. In addition to drugs directly related to treatment, cancer patients may also be taking medicines for pain, nausea, low blood counts and other treatment- or cancer- related symptoms. Some patients may take up to 20 pills a day. Keeping track of all these can be a challenge.

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New Drugs for myeloproliferative neoplasms ease suffering

Details: Several drugs for treating myelofibrosis-related anemia are being tested in clinical trials at MD Anderson, including the activin receptor antagonist sotatercept. Antifibrotic agents. Another new direction in myelofibrosis research is the direct treatment of the fibrosis. Verstovsek said, “We are testing antifibrotic medications that target

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Dealing with the high cost of cancer drugs MD Anderson

Details: The prices of patented cancer drugs in the United States have increased 5- to 10-fold from before 2000 until now, and the cost of new drugs continues to grow far ahead of inflation. The average cancer drug price for approximately 1 year of therapy or a total treatment duration was less than $10,000 before 2000, and had increased to $30,000 to

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Angiogenesis Inhibitors MD Anderson Cancer Center

Details: These drugs are known as tyrosine kinase inhibitors (TKI). Sunitinib (Sutent ®) is an example of a tyrosine kinase inhibitor. While angiogenesis inhibitors work to cut off the tumor’s blood supply, they do not destroy the tumor itself. For this reason, these drugs are typically used in combination with chemotherapy or other treatments.

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Analysis indicates blood cancer drugs are overpriced MD

Details: One of the drugs evaluated, imatinib, was priced at $26,000 per year of therapy in 2001 and $132,000 per year in 2014. The price increase in imatinib and other drugs evaluated is not the result of new and improved versions, but instead is simply the result of rising …

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Chemotherapy MD Anderson Cancer Center

Details: Chemotherapy drugs kill cancer cells, control their growth or relieve disease-related symptoms. Chemotherapy may involve a single drug or a combination of two or more drugs, depending on the type of cancer and how fast it is growing. Chemotherapy can be used as a stand-alone treatment for specific cancers or stages of disease.

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Drugs are Safe, Active in Patients Normally Ineligible for

Details: Drugs are Safe, Active in Patients Normally Ineligible for Clinical Trial. MD Anderson News Release December 10, 2010 Combination given to AML, MDS patients who have second disease and no options. MD Anderson News Release 12/10/10.

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Options increase for CML patients failed by existing drugs

Details: New drugs fill gaps in treatment Ponatinib is the third drug approved by the FDA for CML and Ph+ALL during the past four months, providing oncologists with a wealth of options. Cortes led all of the clinical trials for the three drugs. The other two are bosutinib (Bosulif) and omacetaxine (Synribo).

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Targeting the KRAS mutation for more effective cancer

Details: We haven’t been able to target KRAS mutations with drugs in the past, but newer therapies are now enabling us to directly block specific mutations, like G12C. Through clinical trials, researchers are exploring whether it’s possible to block the downstream signaling pathways, known as the MAPK pathways, which KRAS activates.

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FDA Approves New Drugs for Lung Cancer, Melanoma, 2 Types

Details: All three drugs were available at MD Anderson via clinical trials before FDA approval. "This is an ideal example of personalized therapy," says Faye Johnson, M.D., Ph.D., associate professor in Thoracic /Head and Neck Medical Oncology. "The drug is given only to a small group of patients with the target genetic variation in their tumors.

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Immune Checkpoint Inhibitors MD Anderson Cancer Center

Details: Immune checkpoint inhibitors stop the immune system from turning off before cancer is completely eliminated. They’re a type of immunotherapy. The immune system relies on T cells to fight cancer. These specialized cells are extremely powerful and have the potential to damage healthy cells. T cell activity is controlled through “immune

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Clinical Center for Targeted Therapy MD Anderson Cancer

Details: With some widely-used FDA-approved cancer drugs, only 2% to 20% of patients see a response. “Sometimes, these drugs are only adding days to a patient’s life,” Subbiah says. But in some early-phase clinical trials testing new, experimental targeted therapy drugs, Subbiah and his team have seen 35% to 77% of patients respond well.

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Second-line CML Drugs Evoke Faster, Better Front-line

Details: Drugs likely to increase survival “We’ve learned in cancer therapy that it’s important to use your big guns up front,” Kantarjian said. “We know that achieving complete cytogenetic response or major molecular response within a year of starting treatment is associated with more favorable long-term survival.

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Immunotherapy drug MD Anderson Cancer Center

Details: The drugs have revolutionized melanoma treatment, producing powerful and lasting responses in about 10% to 30% of patients who take one drug only, and in more than 50% of those who take both drugs combined. That still leaves substantial numbers of patients in need of a new approach. For checkpoint blockade to work, there have to be T cells

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Chemotherapy Guide

Details: • Street drugs • Alcohol Cancer Cells To understand cancer therapy, it is helpful to understand cancer cells. Cells are the body’s basic unit of life. Normal body cells grow and divide in a controlled way. Each cell has a certain job in the body and dies after a natural length of time. The body cleans up these dead cells on an ongoing basis.

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ONC201 and 202 drugs potential treatment for blood cancer

Details: The drugs, ONC201 and Onc212, work regardless of whether the common tumor suppressor p53 is present in any form. Findings from the study, led by Michael Andreeff, M.D., Ph.D., professor of Leukemia, and Jo Ishizawa, M.D., Ph.D., assistant professor of Leukemia, were reported in the May 2 online issue of Cancer Cell.

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Q&A: Phase I clinical trials MD Anderson Cancer Center

Details: Q&A: Phase I clinical trials. Phase I clinical trials are the foundation for how we develop new cancer drugs. Typically, they involve only several dozen patients and study a new medicine’s effect on a variety of cancer types. David S. Hong, M.D., sat down with us to explain more about Phase I clinical trials and answer some of patients

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Precision Medicine & Targeted Therapy MD Anderson Cancer

Details: Small molecule drugs can easily enter the cells and interfere with the molecules inside. They can also be used to interfere with molecules on the surface of the cell. Monoclonal antibodies are larger and work outside of cancer cells. They target molecules on the surface of the cancer cells or nearby.

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Examining side effects specific to each targeted drug MD

Details: Antiangiogenic drugs and cardiovascular effects. Another class of drugs with distinct side effects is the targeted antiangiogenic agents, such as the vascular endothelial growth factor (VEGF) inhibitors bevacizumab and aflibercept and the VEGF-targeting multiple tyrosine kinase inhibitors sunitinib, sorafenib, axitinib, cabozantinib, pazopanib

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How to cope with cold sensitivity caused by the

Details: Which chemotherapy drugs cause cold sensitivity? This unique side effect has been linked to a drug called oxaliplatin, which is used to treat several types of cancer, including colorectal cancer, pancreatic cancer, stomach cancer and esophageal cancer. Some people can be more sensitive, but almost everyone gets some degree of cold sensitivity

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Chemotherapy at home: 9 things to know MD Anderson

Details: Chemotherapy drugs require special disposal methods. If you end up not using all of a certain type of chemotherapy pill, or you have tubing or other soiled equipment that was used to administer infusion-based chemotherapy, don’t just toss them out with your regular household trash.

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Anxiolysis (Minimal Sedation) for Procedures and Tests

Details: Assess need for anxiolysis prior to procedure Patient scheduled for procedure or test Note: Refer to UTMDACC Institutional Policy #CLN0502 for complete information. Anxiolysis (Minimal Sedation) for Procedures and Tests

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What is double-hit lymphoma

Details: If we find lymphoma cells in the brain at diagnosis, we add different chemotherapy drugs to R-EPOCH to treat those cells. Patients also used to receive an autologous stem cell transplant . But we’ve seen that if patients have a complete response to the chemotherapy, the stem cell transplant isn’t needed.

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New hepatitis C drugs may strain the system MD Anderson

Details: Study results showed that using the new drugs is cost-effective in the majority of patients. However, the budget required to treat all eligible patients would be $90 billion over the next five years. Compared with the old drugs, new therapies would cost an additional $20 billion, whereas the cost offsets would be …

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What is hand-foot syndrome (Palmar-plantar

Details: Hand-foot syndrome (palmar-plantar erythrodysesthesia) is a side effect caused by certain chemotherapy drugs. Makenna Smack, a clinical pharmacist, discusses which patients are at risk and which symptoms to watch for, as well as when and why prevention is vital.

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Moon shot sets sights on first targeted therapy for triple

Details: Drugs that specifically target a cancer’s genetic abnormality are called targeted therapy or precision medicine. Triple negative is the only form of breast cancer for which there is …

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Brain Metastases Treatment MD Anderson Cancer Center

Details: Several of these drugs are under investigation in clinical trials for patients with specific types of cancer. 8 brain tumor treatment questions, answered. A brain tumor diagnosis and treatment can bring many questions. That’s why John de Groot,

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"Chapter 24: Controversies over Use of Drugs in Clinical

Details: The way this contract operated is that the Cancer Institute developed drugs, and before they went into the clinic, they requested that pharmacology studies be done. We did that on contracts; sent the data back to the project officer. It was a very satisfactory arrangement, and it …

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The man who helped cure childhood leukemia MD Anderson

Details: The man who cured childhood leukemia. A trailblazing oncologist who took on childhood leukemia by introducing combination chemotherapy — in which anticancer drugs are given simultaneously rather than singly — retired in September after 50 years at MD Anderson. Yet Emil J Freireich, M.D., 88, who achieved legendary status as a pioneer in the

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Adult Antiemetic Management of Page 1 of 22 Chemotherapy

Details: No change in antiemetic regimen Consider changes in dosing or other management strategies (i.e., other medications, non-pharmacologic measures)Consider any or all of the following1: Adding a benzodiazepine to the regimen Adding an agent from a different class to …

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Ovarian Cancer Treatment MD Anderson Cancer Center

Details: The drugs also get into the blood and travel through the body. Radiation for Ovarian Cancer. Although radiation therapy rarely is used to treat ovarian cancer, it may help destroy any cancer cells that are left in the pelvic area. It also may be used if the cancer has come back after other treatments. In most cases, the main goal of radiation

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Appendix Cancer Treatment & Surgery MD Anderson Cancer

Details: Surgery. Surgery is the main treatment for appendix cancer. The type of surgery depends on the type of appendix cancer. In some cases, surgery may be combined with chemotherapy, which uses specific drugs to attack fast-growing tumor cells. Carcinoid tumors: Often, surgery is done to remove the appendix, right colon and surrounding lymph nodes.

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How our Investigational Pharmacy Services team gives

Details: Helping bring new drugs to life Most of our investigational protocols are initiated by pharmaceutical companies. Others start as part of federally funded studies or originate with MD Anderson physicians as investigator-initiated trials. Nearly all involve chemotherapy agents. And many target leukemia, like in the blinatumomab case.

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Leukemia Research MD Anderson Cancer Center

Details: Leukemia Research. As one of the world's largest cancer research centers, MD Anderson’s leukemia research experts are leading the effort to better diagnose and treat leukemia. We’re combining excellent patient care with cutting-edge leukemia research through our comprehensive clinical trials portfolio, which offers patients with diverse and

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How is nanomedicine used in cancer treatment

Details: This is the next frontier of designing drugs. The goal of chemotherapy is to kill the cancer by giving the patient as much of the drug as possible. As a result, the whole body receives this massive dose of drugs, which causes hair loss, diarrhea and nausea. However, nanomedicine provides a strategy to deliver anti-cancer or immunotherapy drugs

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Partnership yields new immunotherapy drug and a clinical

Details: No drugs targeting OX40 have earned FDA approval. While checkpoint blockade drugs have shown strong results for some patients, combination therapies are considered the key to extending and improving outcomes for more patients. The GSK agreement led to the development of ORBIT, a spin-off of MD Anderson’s Institute for Applied Cancer Science

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A Parallel Phase I/II Clinical Trial Design for

Details: true for many drugs, it is false for some. In combination drug therapy, the MTDs form a curve in a two-dimensional plane. The location of the optimal combination dose on the curve is unknown. Therefore, a trial of drugs in combination re-quires a dose-selection procedure that is …

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Possible side effects of immunotherapy — and how to handle

Details: First, fewer patients experience side effects on the drugs targeting PD-1 (e.g., pembrolizumab and nivolumab) as well as those targeting PD-L1 (e.g., atezolizumab, avelumab and durvalumab). “With the previous generation of CTLA-4 drugs (ipilimumab), we see more toxicities, and they’re more likely to be life-threatening,” Subbiah says.

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The drug that may make chemo a thing of the past MD

Details: New drugs are in the pipeline. Idelalisib blocks a different molecular pathway called PI3K. O’Brien co-led a clinical trial of the drug combined with rituximab, compared with rituximab alone, for heavily pretreated CLL patients who weren’t eligible for chemotherapy combinations.

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Novel targeted drug induced positive response for patients

Details: In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)–associated renal cell carcinoma (RCC).

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Extravasation1 Management (Vesicant and Contrast Agents

Details: 1 Refer to Appendix F for Antidote Dosing and Administration 2 Hyaluronidase should be avoided with vasopressor and taxane related extravasations as it may worsen outcomes 3 For extravasated vesicants that do not have effective antidotes available, local non-pharmacologic measures and close monitoring are important. Non-cytotoxic vesicant extravasations typically are best managed with WARM

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Immunotherapy for lung cancer: Researchers working to

Details: Immunotherapy drugs that free the immune system to attack cancer have provided durable responses for about 20 percent of lung cancer patients, which has provided a pair of challenges to researchers:. Identifying patients in advance of treatment who will benefit from immune checkpoint blockade drugs. Extending effective immunotherapy to more patients.

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Chemo Side Effects: Sexuality and Cancer MD Anderson

Details: Vomiting. Diarrhea. Constipation. Hair loss. Weight changes. Scars. Sensitivity to tastes and smells. While medications are available to treat many of these symptoms, some of these same drugs can decrease sexual desire or make it harder to reach orgasm. It is usually safe to have sex during cancer treatment unless your doctor tells you not to.

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Treating Uveal Melanoma MD Anderson Cancer Center

Details: Through the years, he has created a comprehensive clinical database on uveal melanoma, containing the clinical outcomes of the different treatments and drugs that he has tested in trials for these patients. Information on our melanoma treatments and melanoma clinical trials is available online and by calling 1-713-792-3245 or (toll free) 1-877

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