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Multispecific drugs herald a new era of biopharmaceutical

Details: For 50 years, the application of 1T1D approaches with conventional biologic and small-molecule drugs has reigned supreme, but a sea change is now sweeping over the industry. Pipelines are

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Natural products in drug discovery: advances and

Details: The increasing significance of drugs not conforming to this rule is illustrated by the increase in molecular mass of approved oral drugs over the past 20 years 12.

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Trends in peptide drug discovery Nature Reviews Drug

Details: Peptide drugs occupy a distinct pharmaceutical space in between small-molecule drugs and biologics. a | They account for 5% of the global pharmaceutical market, with global sales exceeding US$50

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A comprehensive map of molecular drug targets Nature

Details: The 154 cancer drugs approved by the FDA can be broadly divided into the three groups mentioned above: 26 drugs are cytotoxic agents; 38 drugs are broadly cytotoxic and act at least partially

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Drugs, their targets and the nature and number of drug

Details: All drugs somehow interfere with signal transduction, receptor signalling and biochemical equilibria. For many drugs we know, and for most we suspect, that they interact with more than one target.

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Advances in oligonucleotide drug delivery Nature Reviews

Details: Oligonucleotide-based drugs have the potential to treat or manage a wide range of diseases. However, the widespread application of such therapies has been hampered by the difficulty in achieving

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Drug ranking using machine learning systematically

Details: Drugs were filtered by an interquartile range > 0.15 AAC units to ensure that there was a sufficient range of sensitivity, thus reducing the number of profiled drugs from 659 to 466.

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Drugs: More shots on target Nature

Details: Drugs introduced to fight multiple myeloma in the past decade have revolutionized treatment and extended patients' lives. Are the improvements set to continue?

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African scientists race to test COVID drugs — but face

Details: African scientists race to test COVID drugs — but face major hurdles. In a bid to stave off looming disaster, scientists are trying to repurpose drugs used for malaria and other diseases, but

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Automating drug discovery Nature Reviews Drug Discovery

Details: One may also envisage automated drug discovery platforms that include modules for dynamic combinatorial chemistry with biocompatible reactions; that is, the in situ generation of drugs binding to

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On-target versus off-target effects of drugs inhibiting

Details: Drugs that are currently in clinical evaluation have been selected based on their capacity to inhibit SARS-CoV-2 replication in vitro or to dampen excessive inflammatory reactions in response to

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One step conjugation of some chemotherapeutic drugs to the

Details: Drugs preparation. The concentration of the tablet form drugs was determined using UV-visible spectrophotometer. Based on the obtained ODs, the concentration of capecitabine was 54 …

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Drugs targeting the renin–angiotensin–aldosterone system

Details: Drugs that inhibit or antagonize components of the renin–angiotensin–aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional

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COVID antiviral pills: what scientists still want to know

Details: The antiviral drugs molnupiravir and Paxlovid can cut COVID-19 hospitalizations when people are treated soon after becoming infected with the coronavirus. Credit: Sergei Supinsky/AFP via Getty

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COVIDrugNet: a network-based web tool to investigate the

Details: The COVID-19 Drugs Networker (COVIDrugNet, Fig. 1) is a web tool designed for the exploration of the landscape of the drugs currently in clinical trials to combat the SARS-CoV-2 infection. The web

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Drug addiction: bad habits add up Nature

Details: We know how many drugs of abuse – cocaine, heroin and nicotine – work, but less about how they lead to addiction. Studies of the brain-learning systems concerned are addressing the causes of

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mRNA-based therapeutics — developing a new class of drugs

Details: The concept of nucleic acid-encoded drugs was conceived over two decades ago when Wolff et al. 1 demonstrated that direct injection of in vitro transcribed (IVT) mRNA or plasmid DNA (pDNA) into

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The resurgence of covalent drugs Nature Reviews Drug

Details: Covalent drugs haveproved to be successful therapies for various indications, but largely owing to safety concerns, they are rarely considered when initiating a target-directed drug discovery project.

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Biochemical mechanisms of drug action: what does it take

Details: These drugs have extremely slow dissociation rates and are insurmountable in functional assays (D. C. S. and M. Rose, unpublished results) 20,22,34. The insurmountable behaviour of these drugs is

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The discovery of first-in-class drugs: origins and

Details: a | First-in-class drugs were classified according to whether they were discovered in a systems-based, target-agnostic manner or using a hypothesis-driven, target-based approach. Central to the

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NOD: a web server to predict New use of Old Drugs to

Details: Computational methods accelerate the drug repurposing pipelines that are a quicker and cost-effective alternative to discovering new molecules. However, there is a paucity of web servers to

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Drug repurposing: progress, challenges and recommendations

Details: Drug repurposing (also called drug repositioning, reprofiling or re-tasking) is a strategy for identifying new uses for approved or investigational drugs that are outside the scope of the original

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Drugs, medications and periodontal disease British

Details: The drugs that have been studied most often with respect to periodontal diseases are the corticosteroids, the non-steroidal anti-inflammatory drugs (NSAIDs) and more recently, biological therapies

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Health agency reveals scourge of fake drugs in developing

Details: Malaria drugs and antibiotics are among the most commonly reported, the agency found. But the problem extends to a variety of medications, including those for cancer, heart disease and HIV, as

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Intracellular delivery of protein drugs with an

Details: Delivering protein drugs into the cytoplasm of cancer cells would expand the number of treatable cancer targets. More than 60% of the pathways that control cellular function are intracellular 1

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Counting on natural products for drug design Nature

Details: Natural products and their intricate molecular frameworks offer medicinal chemists a range of uncharted chemotypes for the discovery of chemical probes and drugs 1,2,3,4,5,6,7.Natural products

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More Alzheimer’s drugs head for FDA review: what

Details: The FDA can approve Alzheimer’s drugs on the basis of their ability to remove amyloid-β from the brain — without clear evidence of cognitive benefit. Pharma watchers therefore think that an

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Bioaccumulation of therapeutic drugs by human gut bacteria

Details: Therapeutic drugs can have a strong effect on the gut microbiome and vice versa 2,3,4,5.The underlying drug–bacteria interactions can reduce microbial fitness 6 or alter drug availability

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Coronapod: new hope from COVID antiviral drugs

Details: Two antiviral drugs could change the course of the pandemic, but scientists still have questions. Two new antiviral pills have been shown to be safe and effective against COVID in clinical trials

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Drug repositioning: identifying and developing new uses

Details: The process of finding new uses outside the scope of the original medical indication for existing drugs is known as drug repositioning. Repositioning existing drugs for new indications can offer a

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Microtubules as a target for anticancer drugs Nature

Details: Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids, were previously considered to work primarily by increasing or decreasing the cellular microtubule mass. Although these effects

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Nephrotoxic effects of designer drugs: synthetic is not

Details: Designer drugs are synthesized to produce effects similar to scheduled or controlled chemical compounds. These drugs are used as 'legal highs' and are undetectable by standard toxicology tests

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Drugs of Abuse and the Aging Brain Neuropsychopharmacology

Details: Whereas alcohol and prescription drugs remain the most commonly abused substances among older adults, several lines of evidence suggest that abuse of illicit drugs in this population is on the rise.

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Exploring the SARS-CoV-2 virus-host-drug interactome for

Details: Drugs currently undergoing clinical trials and mappable to DrugBank IDs (as of April 4, 2020) for the treatment of COVID-19 were collected from ClinicalTrials.gov (www.ClinicalTrials.gov) 41, the

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Oncolytic viruses: a new class of immunotherapy drugs

Details: The inclusion of 'suicide genes' (genes that render cells more sensitive to apoptosis or therapy with other drugs) into oncolytic viruses can enhance their ability to directly kill cancer cells 93

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Identification of SARS-CoV-2 entry inhibitors among

Details: A library of 1800 approved drugs was screened to determine the effects on blocking SARS2-S pseudovirus infection activity (@20 µM). A set of 154 drugs

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New hope for anti-obesity drugs

Details: With the FDA’s approval of Novo Nordisk’s diabetes drug semaglutide for chronic weight management, the anti-obesity drug development community now has a chance to overcome the disappointments

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MicroRNA in combination with HER2-targeting drugs reduces

Details: The effect of the HER2-targeting drugs alone in KPL4 cells was a 4% reduction in viability due to trastuzumab, while lapatinib lowered the viability with 17% and finally, the combination of

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Precision medicine in IBD: genes, drugs, bugs and omics

Details: Regardless of the drugs used, clinical response and remissions are comparable, indicating that a therapeutic ceiling has been reached, and novel strategies to overcome it are currently under

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The manipulation of apoptosis for cancer therapy using BH3

Details: BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the

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Drugs go wireless Nature Biotechnology

Details: Drugs go wireless. Electronic drugs and delivery systems are reaching the market, giving drug developers and healthcare providers a way to improve patient compliance and more. Emily Waltz reports

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Small molecular drugs reshape tumor microenvironment to

Details: Small molecular antitumor drugs might induce tumor cell deaths to provoke innate sensing pathways, or directly activate innate sensing pathways, or target other immunosuppressive factors in TME to

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Incretin drugs for glycaemic control

Details: Incretin drugs for glycaemic control. Over the past 15 years, drugs targeting the incretin hormones ( Milestone 9 ), including glucagon-like peptide 1 (GLP1), have emerged as effective anti

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Antipsychotics for negative and positive symptoms of

Details: For these drugs, higher doses of treatment were associated with less improvement of negative symptoms. The curves for risperidone and sertindole also descended with higher doses, but the effect

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Trends in oncology drug innovation in China

Details: Oncology has been at the forefront of this transition. Indeed, 12 out of 44 of the new cancer drugs approved in China in between 2018 and August 2020 were discovered in China. Although most were

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Plasmonic nanoparticle amyloid corona for screening Aβ

Details: Effective screening of drugs to treat amyloid oligomeric aggregates associated with Alzheimer’s is needed for drug development. Here the authors report on the creation of an amyloid corona

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Lipids and lipid-based formulations: optimizing the oral

Details: Lipophilic, poorly water-soluble drug candidates are common outcomes of drug discovery programmes. Porter and colleagues discuss mechanisms by which lipids and lipidic excipients can improve oral

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Repurposing cancer drugs identifies kenpaullone which

Details: Yeo, M., Chen, Y., Jiang, C. et al. Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission.

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