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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: anxiolytic drugs. 1.1 Pediatrics Pediatrics (< 18 years of age): No data are available to Health Canada; therefore, Health Canada has not authorized an indication for pediatric use. 1.2 Geriatrics Evidence from clinical studies and experience suggests that use in the geriatric population is associated with differences in safety or effectiveness.

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: Drugs that cause QT/QTc prolongation are suspected of increasing the risk of torsade de pointes. Torsade de pointes is a polymorphic ventricular tachyarrhythmia. Generally, the risk of torsade de pointes increases with the magnitude of QT/QTc prolongation produced by the …

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: Product Monograph Moderna COVID-19 Vaccine, mRNA-1273 SARS-CoV-2 vaccine Page 5 of 23 4.3 Reconstitution Moderna COVID-19 Vaccine must not be reconstituted, mixed with other medicinal products, or

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: As with other drugs, caution should be used in the treatment of elderly patients who are more likely to be suffering from impaired renal, hepatic or cardiac function. 2 CONTRAINDICATIONS ACETAMINOPHEN INJECTION is contraindicated in: patients who have previously demonstrated hypersensitivity to acetaminophen, to

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: prolonging drug or drugs that can cause electrolyte imbalance. When drugs that prolong the QTc interval are prescribed, healthcare professionals should counsel their patients concerning the nature and implications of the ECG changes, underlying diseases and disorders that are considered to represent risk factors, demonstrated and predicted

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PRODUCT MONOGRAPH PFIZER-BIONTECH COVID-19 VACCINE

Details: Pfizer-BioNTech COVID-19 Vaccine [COVID-19 mRNA Vaccine] Product Monograph Page 2 of 28 TABLE OF CONTENTS Sections or subsections that are not applicable at the time of authorization are not listed.

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: opioids, alcohol or illicit drugs. Assess each patient’s risk prior to prescribing DIASTAT Monitor all patients regularly for the development of these behaviours or conditions. DIASTAT should be stored securely to avoid theft or misuse. Withdrawal Benzodiazepines, like DIASTAT, can produce severe or life-threatening withdrawal symptoms.

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16 mg / 12.5 mg, 32 mg / 12.5 mg and 32 mg / 25 mg

Details: containing drugs, is generally not recommended in other patients, since such treatment has been associated with an increased incidence of severe hypotension, decreased renal function (including acute renal failure), and hyperkalemia. Avoid the concomitant use of ACE inhibitors and ARBs in patients with diabetic nephropathy.

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PRESCRIBING INFORMATION INCLUDING PATIENT …

Details: Antibacterial drugs like MAR-DAPSONE treat only bacterial infections. They do not treat viral infections such as the common cold. Although you may feel better early in treatment, MAR-DAPSONE should be used exactly as directed. Misuse or overuse of MAR-DAPSONE could lead to the growth of bacteria that will not be killed by MAR-DAPSONE (resistance).

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PRODUCT MONOGRAPH IMOVANE (zopiclone) Tablets, 5.0 …

Details: reported to occur in association with the use of drugs that act at the benzodiazepine receptors. IMOVANE should be used with caution in patients who in the past manifested paradoxical reactions to alcohol and/or sedative medications. Lactose is a non-medicinal ingredient in IMOVANE 5 mg. Patients with rare hereditary diseases

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Product Monograph

Details: During treatment with all antisecretory drugs serum gastrin increases in response to the decreased acid secretion. The effect of NEXIUM on serum gastrin concentrations was evaluated in approximately 2,700 patients in clinical trials up to 8 weeks and in over 1,300 patients for up to 6-12 months (daily doses of either 20 or 40 mg).

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PRODUCT MONOGRAPH MESTINON Tablets, 60 mg …

Details: many drugs are excreted in human milk, and because of the potential for serious adverse reactions from pyridostigmine in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use: See Dosage and Administration Section.

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: Anticholinergic drugs may aggravate or precipitate these conditions. Use CUVPOSA with caution in these patients. Cardiac function and status should be monitored as appropriate, if needed in these patients. Gastrointestinal Constipation is a common dose-limiting adverse reaction which sometimes leads to

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: other drugs that reduce the seizure threshold. Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections). In tramadol overdose, naloxone administration

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PRODUCT MONOGRAPH

Details: Drugs or medicinal products that can significantly impact renal function (ex: memantine, NSAIDS) may reduce baclofen excretion leading to toxic effects (see WARNINGS, Impaired Renal Function). Drugs causing Central Nervous System (CNS) depression Increased sedation may occur when baclofen is taken concomitantly with other drugs causing

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PRODUCT MONOGRAPH DIAZEPAM Anxiolytics: …

Details: drugs for use in patients for whom alternative treatment options are inadequate. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to …

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PRESCRIBING INFORMATION

Details: following drugs should be avoided because of likely occurrence of adverse effects: alcohol, anaesthetics and CNS depressants and to a lesser extent, acetaminophen, oral anticoagulants, carbamazepine, oral contraceptives, estrogens, cor ticosteroids, digitalis, digitoxin, tricyclic .

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PRODUCT MONOGRAPH Carboplatin Injection Teva Standard …

Details: chemotherapeutic drugs. Blood counts as well as renal and hepatic function tests must be done regularly and the drug should be discontinued if abnormal depression of the bone marrow or abnormal renal or hepatic function is seen. Its carcinogenic potential has not been studied, but compounds with similar mechanisms of

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PRODUCT MONOGRAPH BONAMINE Meclizine …

Details: comparator drugs, promethazine and scopolamine, a fforded equivalent or better protection, each of these had to be administered 1 hour before flights to be effective, and were limited in their usefulness by side effects. In a field study involving 12 susceptible service pe rsonnel aboard a U.S. Coast Guard cutter, daily

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PRODUCT MONOGRAPH Nadolol Tablets USP 40, 80 and 160 …

Details: used in combination with other drugs, particularly a thiazide diuretic. However, it may be tried alone as an initial agent in those patients in whom, in the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. The combination of nadolol with a diuretic has been found to be compatible and generally more

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PRESCRIBING INFORMATION ATIVAN

Details: Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation. Ativan (lorazepam) is an active benzodiazepine with a depressant action on the central

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PRESCRIBING INFORMATION LARGACTIL

Details: drugs relieving pain, to control nausea and vomiting or to prevent and treat shock following the surgery. Ask your doctor if you have any questions about why Largactil® has been prescribed to you. What it does: Largactil® helps to: reduce and control psychotic symptoms and induce sleep which can control various states of emotional tension,

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: benzodiazepines, barbiturates, and antiepileptic drugs, or using other bupropion-containing products. Caution should be used when prescribing CONTRAVE to patients with predisposing factors that may increase the risk of seizure including: history of head trauma or prior seizure, severe stroke, arteriovenous malformation, central

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PRESCRIBING INFORMATION

Details: The drugs listed below are based on either drug interaction case reports or studies, or potential interactions due to the expected magnitude and seriousness of the interaction. Anticholinergics / antispasmodics – Additive anticholinergic effects may occur if benztropine is

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: Concomitant use of IMBRUVICA® and drugs that strongly induce CYP3A decreases ibrutinib exposure and should be avoided (see DRUG INTERACTIONS). IMBRUVICA® may increase the exposure of drugs that undergo BCRP-mediated hepatic efflux, such as rosuvastatin. Dose reduction of these concomitant drugs may be necessary (see DRUG INTERACTIONS).

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PRODUCT MONOGRAPH

Details: If such drugs are used, they should be administered with an interval of at least 5 minutes between applications. There have been reports of paradoxical elevations in IOP following the concomitant ophthalmic administration of two prostaglandin analogs. Therefore, the use of two or more prostaglandins,

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VAXZEVRIA™ COVID-19 Vaccine (ChAdOx1-S [recombinant

Details: drugs.html#a2.8 AstraZeneca Canada Inc. 1004 Middlegate Road Mississauga, Ontario L4Y 1M4 www.astrazeneca.ca Date of Initial Authorization: February 26, 2021 Date of Revision: September 15, 2021 Submission Control Number: 255966 .

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PRODUCT MONOGRAPH

Details: along with drugs which may produce impaired renal function. Uricosuric drugs, such as probenecid and sulfinpyrazone, may inhibit renal tubular secretion of nitrofurantoin. The resulting increase in serum levels may increase toxicity and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial.

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PRESCRIBING INFORMATION TEVA-LORAZEPAM

Details: Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation. TEVA-LORAZEPAM (lorazepam) is an active benzodiazepine with a depressant action on

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PRODUCT MONOGRAPH

Details: drugs are equipotent. A similar species difference was also observed in anti-granuloma activity. When anti-granuloma activity was determined in mice, using cotton wool pellets soaked in carrageenan, clobetasol 17-propionate was 5 times as potent as betamethasone alcohol, when given subcutaneously.

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PRODUCT MONOGRAPH Hp-PAC

Details: Drug Interactions with Antiretroviral Drugs PPIs have been reported to interact with some antiretroviral drugs. The clinical importance and the mechanisms behind these interactions are not always known. A change in gastric pH may change the absorption of the antiretroviral drug. Other possible mechanisms are via CYP 2Cl9. Rilpivirine

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PRESCRIBING INFORMATION AND PATIENT MEDICATION …

Details: May result in diminution of the effects of both drugs on the gastrointestinal tract. Beta-adrenergic agents May enhanced tachycardic effects. Antacids or adsorbent antidiarrheals May reduce the absorption of anticholinergics, resulting in decreased therapeutic effectiveness. Anticholinergics such as hyoscine butylbromide should

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PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION …

Details: Pfizer-BioNTech COVID-19 Vaccine [COVID-19 mRNA Vaccine] Product Monograph Page 2 of 26 TABLE OF CONTENTS Sections or subsections that are not applicable at the time of authorization are not listed.

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[Product Monograph Template

Details: Drugs known to induce these enzyme systems may result in an increased metabolism of tacrolimus or decreased bioavailability as indicated by decreased whole blood or plasma levels. Monitoring of blood levels and appropriate dosage adjustments in transplant patients are essential when such drugs are used concomitantly (see Drug Interactions.)

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PrAPO-ARIPIPRAZOLE

Details: the adverse effects of atypical antipsychotic drugs on weight, glucose and lipid metabolism can be greater in antipsychotic-naïve pediatric and adolescent patients than in patients who have been treated previously with antipsychotic drugs. ). .

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PRODUCT MONOGRAPH STEMETIL prochlorperazine as

Details: Neuroleptic drugs elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin-dependent in vitro, a factor of potential importance if the prescription of these drugs is

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PRODUCT MONOGRAPH

Details: epileptic drugs associated with SJS/TEN should be avoided in patients who test positive for the HLA-A*3101 or HLA-B*1502 alleles (see WARNINGS AND PRECAUTIONS, Ancestry and Allelic Variations in the HLA-A Gene; Ancestry and Allelic Variation in the HLA-B Gene; Important Limitations of HLA-A and HLA-B Genotyping).

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PRESCRIBING INFORMATION

Details: Concomitant therapy with other drugs or herbal substances known to induce hypokalemia (e.g., thiazide diuretics, adrenocorticosteroids and liquorice root) may enhance the electrolyte imbalance. Hypokalemia potentiates the action of cardiac glycosides and interacts with antiarrhythmic medications.

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PRODUCT MONOGRAPH

Details: including some drugs used for managing multiple sclerosis. Due to the potential for severe liver injury, exercise caution and closely monitor patients if other known or potentially hepatotoxic drugs are used in combination with AUBAGIO or if there is a history of drug-induced

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PRODUCT MONOGRAPH GLYCOPYRROLATE INJECTION USP …

Details: bradycardia and intestinal hypermotility) induced by cholinergic drugs such as anticholinesterases. As a premedicant, Glycopytrolate Injection USP reduces excessive pharyngeal, tracheal and bronchial secretions and, during anesthesia, it appears to protect the heart against excessive vagal stimulation.

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TEVA-LENOLTEC No. 1

Details: drugs, salicylates, any other pain and fever relief medication or nonsteroidal anti-inflammatory drugs (NSAIDS). Keep out of the sight and reach of children. Codeine is habit forming and potentially abusable. Consequently, the extended use of this product is not recommended.

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PRODUCT MONOGRAPH

Details: An FDA meta-analysis of placebo-controlled clinical trials of antidepressant drugs in adult patients ages 18 to 24 years with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo. Families and caregivers of patients being treated with sertraline should be alerted about

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154593 TEVA-CHLORPROMAZINE APM

Details: the drugs of choice are alpha-receptor agonists such as phenylephrine or methoxamine. The use of epinephrine in these cases should be avoided as it may cause a further fall in blood pressure. Dependence/Tolerance Abrupt Withdrawal: In general, phenothiazines do not produce psychic dependence; however,

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PRODUCT MONOGRAPH ADDERALL XR Central Nervous …

Details: drugs that effect urinary pH are known to alter the elimination of amphetamine, and any decrease in amphetamine’s metabolism that might occur due to drug interactions or genetic polymorphisms is more likely to be clinically significant when renal elimination is decreased (see PRECAUTIONS, Drug Interactions).

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Mycophenolate Mofetil for Injection USP

Details: Drugs which interfere with MPA’s enterohepatic cycle (e.g. cholestyramine, sevelamer, antibiotics) should be used with caution due to their potential to reduce the plasma levels and efficacy of Mycophenolate Mofetil for Injection USP (see Drug-Drug Interactions). Therapeutic drug monitoring of MPA may be appropriate

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PRODUCT MONOGRAPH GRAVOL

Details: Drugs with Anticholinergic Effects: Because dimenhydrinate also has anticholinergic activity, it may potentiate the effects of other drugs with anticholinergic activity including tricyclic antidepressants, MAO inhibitors, and antihistamines. Solid potassium dose forms should be

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COMPLETE PRESCRIBING INFORMATION

Details: decrease of plasma levels of enzymatic inductor anticonvulsant drugs may be observed because the hepatic metabolism is increased as folates are one of the cofactors). 33, 34 When leucovorin calcium is given in conjunction with a folic acid antagonist (eg, cotrimoxazole, pyrimethamine, methotrexate, antibiotic with antifolic effect) the efficacy of

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PRODUCT MONOGRAPH ELAVIL amitriptyline hydrochloride

Details: Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome CYP 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from cotherapy, an increased dose of tricyclic antidepressant may be required.

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