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Details: The Related Drug Information Index provides comprehensive access to all drug information related to a specific drug Types of content include full prescribing information, drug summaries, Full Prescribing Information Continuing Medication Education (Full PI CME), Medication Guides, Risk Evaluation and Mitigation Strategies (REMS Summaries), REMS Continuing Medication Education (REMS CME), and

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PDR Drug Updates PDR.net

Details: PDR, Phsycians' Desk Reference, delivers a monthly electronic drug update, eDrug Update, containing FDA updates, FDA recalls, and FDA approvals, to all registered PDRnet prescribers Get access to monthly eDrug Update content with important labeling update information and …

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Browse by Drug Name PDR.net

Details: Browse by Drug Name. Browse PDR's full list of drug information alphabetically by choosing the first letter of the drug you are tying to locate. A.

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Isoniazid Tablets (isoniazid) dose, indications, adverse

Details: These drugs are often used together for the treatment of active tuberculosis (TB) infection, and patients should also be assessed for additional risk factors for hepatotoxicity, such as other hepatotoxic drugs, alcohol use, and underlying hepatic disease. Rifampin can increase the metabolism of isoniazid, INH into a hepatotoxic metabolite

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Sonata (zaleplon) dose, indications, adverse effects

Details: Other drugs that may have additive CNS effects with zaleplon but have not been studied include other tricyclic antidepressants. If used together, a reduction in the dose of one or both drugs may be needed. Amobarbital: (Major) Coadministration of zaleplon and barbiturates may result in additive CNS depression. Caution should be exercised during

› Verified 7 days ago

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Coreg (carvedilol) dose, indications, adverse effects

Details: Drugs that reduce catecholamine uptake or deplete catecholamine stores, such as carvedilol, may interfere with iobenguane I-131 uptake into cells and interfere with dosimetry calculations resulting in altered iobenguane I-131 efficacy. Irinotecan Liposomal:

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Nitrostat (nitroglycerin) dose, indications, adverse

Details: Nesiritide, BNP: (Major) The potential for hypotension may be increased when coadministering nesiritide with other vasodilators or hypotensive drugs, such as nitrates. Nitroprusside: (Moderate) Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Dosage adjustments may be necessary.

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Digoxin (digoxin) dose, indications, adverse effects

Details: Digoxin is a P-glycoprotein (P-gp) substrate with a narrow therapeutic index and apalutamide is a weak P-gp inducer. Drugs that induce P-gp have the potential to alter digoxin pharmacokinetics. Apraclonidine: (Minor) No specific drug interactions were identified with systemic agents and apraclonidine during clinical trials. It is theoretically

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Urecholine (bethanechol chloride) dose, indications

Details: Thus, these drugs can antagonize the beneficial actions of bethanechol on GI motility. Oxybutynin: (Major) The muscarinic actions of drugs known as parasympathomimetics, including both direct cholinergic receptor agonists and cholinesterase inhibitors, can antagonize the antimuscarinic actions of anticholinergic drugs, and vice versa.

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Reglan Tablets (metoclopramide) dose, indications, adverse

Details: Both drugs are associated with extrapyramidal symptoms and rarely, neuroleptic malignant syndrome. Additive sedation is also possible. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Caution is warranted when cobicistat is administered with metoclopramide as there is a potential for elevated metoclopramide and

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Ibuprofen Tablets (ibuprofen) dose, indications, adverse

Details: Nonsteroidal antiinflammatory drugs (NSAIDs) are associated with esophageal and/or gastric irritation, GI ulceration. a risk of nephrotoxicity, and decreased bone mineral density. Bisphosphonates may cause GI adverse events and occasionally, renal dysfunction. Though patients receiving intravenously administered bisphosphonates have a decreased

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Saphris (asenapine) dose, indications, adverse effects

Details: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with droperidol include asenapine. Dulaglutide: (Moderate) Atypical antipsychotic therapy may aggravate diabetes mellitus and cause metabolic changes such as hyperglycemia. Monitor patients on antidiabetic agents for worsening glycemic control.

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Lasix (furosemide) dose, indications, adverse effects

Details: Drugs that are associated with depletion of electrolytes may cause cisapride-induced cardiac arrhythmias. Cisatracurium: (Moderate) Concomitant use of neuromuscular blockers and loop diuretics may prolong neuromuscular blockade, possibly due to hypokalemia or alterations in potassium concentrations across the end-plate membrane.

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Claritin (loratadine) dose, indications, adverse effects

Details: These 2 drugs should not be given at the same time due to the duplication of therapy and the resultant increase in desloratadine concentrations, which may lead to increased CNS or anticholinergic effects. Desloratadine; Pseudoephedrine: (Major) Desloratadine is the active metabolite of Loratadine. These 2 drugs should not be given at the same

› Verified 7 days ago

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Sodium Chloride (sodium chloride) dose, indications

Details: Sodium chloride ophthalmic formulations (i.e., 2% and 5% ophthalmic solution and 5% ophthalmic ointment) have been associated with temporary ocular irritation and burning; however if ocular redness and irritation continue or if recipients experience ocular pain or changes in vision (i.e., visual impairment), use of the drugs should be discontinued.

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Bentyl (dicyclomine hydrochloride) dose, indications

Details: Avoid drugs with strong anticholinergic properties in geriatric patients with the following conditions due to the potential for symptom exacerbation or adverse effects: dementia/cognitive impairment (adverse CNS effects), delirium/high risk of delirium (new-onset or worsening delirium), or lower urinary tract symptoms/benign prostatic

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Zarontin Capsules (ethosuximide) dose, indications

Details: These drugs used in combination may result in elevated ethosuximide plasma concentrations, causing an increased risk for ethosuximide-related adverse events. Prochlorperazine: (Moderate) Concomitant use of ethosuximide with phenothiazines can lower the seizure threshold and reduce the effectiveness of ethosuximide as an anticonvulsant.

› Verified 8 days ago

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Cialis (tadalafil) dose, indications, adverse effects

Details: Because many drugs are excreted in human breast milk, use tadalafil with caution in breast-feeding women.[40259] MECHANISM OF ACTION Tadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

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Ampicillin Capsules and Oral Suspension (ampicillin

Details: Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Another review concurred with these data, but noted that individual patients have been

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Ditropan XL (oxybutynin chloride) dose, indications

Details: These drugs used in combination may result in elevated oxybutynin plasma concentrations, causing an increased risk for oxybutynin-related adverse events. Potassium: (Major) Drugs that decrease GI motility may increase the risk of GI irritation from sustained-release solid oral dosage forms of potassium salts. The use of solid oral dosage forms

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Viagra (sildenafil citrate) dose, indications, adverse

Details: If these drugs are administered concurrently, monitor the patient for signs of toxicity or lack of efficacy. Pazopanib: (Moderate) Pazopanib is a weak inhibitor of CYP3A4. Coadministration of pazopanib and sildenafil, a CYP3A4 substrate, may cause an increase in systemic concentrations of sildenafil.

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Nardil (phenelzine sulfate) dose, indications, adverse

Details: In a pooled analysis of placebo-controlled trials of antidepressants (n = 4,500 pediatrics and 77,000 adults), there was an increased risk for suicidal thoughts and behaviors in patients 24 years of age and younger receiving an antidepressant versus placebo, with considerable variation in the risk of …

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Acetylcysteine (acetylcysteine) dose, indications, adverse

Details: PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice PDR's drug summaries are available free of charge and serve as a great resource for US based MDs, DOs, NPs and PAs in …

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MiraLax (polyethylene glycol 3350) dose, indications

Details: Drugs used to treat constipation, such as laxatives, would counteract the effect of antidiarrheals. In general, it would be illogical to concurrently administer these drugs at the same time. If an antidiarrheal medication is needed, it would be wise to temporarily discontinue use of agents with laxative effects.

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Polymyxin B (polymyxin B sulfate) dose, indications

Details: Drugs that decrease renal function may also increase concentrations of tenofovir. Renal impairment, which may include hypophosphatemia, has been reported with the use of tenofovir with a majority of the cases occurring in patients who have underlying systemic or renal disease or who are concurrently taking nephrotoxic agents. Monitor patients

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Azithromycin (azithromycin) dose, indications, adverse

Details: Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Another review concurred with these data, but noted that individual patients have been

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Osmitrol (mannitol) dose, indications, adverse effects

Details: Verteporfin is a light-activated drug used in photodynamic therapy. Once activated, highly reactive, short-lived singlet oxygen and reactive oxygen radicals are generated. Concomitant use of drugs that quench active oxygen species or scavenge radicals, such as mannitol, would …

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Mitoxantrone (mitoxantrone) dose, indications, adverse

Details: Myelosuppressive drugs, such as mitoxantrone, can cause an increased incidence of bacterial, viral, and fungal infection, bleeding, and fatigue due to neutropenia, thrombocytopenia, and anemia. Because these adverse effects can be fatal, the patient must be warned to promptly report any signs such as fever, sore throat, or abnormal pain.

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Xarelto (rivaroxaban) dose, indications, adverse effects

Details: Nonsteroidal antiinflammatory drugs: (Major) An additive risk of bleeding may be seen in patients receiving anticoagulants in combination with other agents known to increase the risk of bleeding such as nonsteroidal antiinflammatory drugs (NSAIDs). Monitor clinical and …

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amphetamine aspartate monohydrate/amphetamine sulfate

Details: Thiazide diuretics and related drugs like indapamide may increase urinary pH, acting as a urinary alkalinizer, thus reducing urinary excretion and increasing blood concentrations of the amphetamine. Co-administration of amphetamines and urinary alkalinizing agents should be avoided if possible. If needed, monitor for common amphetamine side

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Plavix (clopidogrel bisulfate) dose, indications, adverse

Details: Verteporfin is a light-activated drug. Once activated, local damage to neovascular endothelium results in a release of procoagulant and vasoactive factors resulting in platelet aggregation, fibrin clot formation, and vasoconstriction. Concomitant use of drugs that decrease platelet aggregation could decrease the efficacy of verteporfin therapy.

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Pitocin (oxytocin) dose, indications, adverse effects

Details: The concurrent use of carboprost tromethamine and other oxytocic drugs is not recommended. Chlophedianol; Guaifenesin; Phenylephrine: (Major) The administration of prophylactic vasopressors with oxytocin can cause severe, persistent hypertension, as the 2 drugs may have a synergistic and additive vasoconstrictive effect. This interaction was

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Losartan Potassium (losartan potassium) dose, indications

Details: Losartan is a substrate of CYP3A; grazoprevir is a weak CYP3A inhibitor. If these drugs are used together, closely monitor for signs of adverse events. Elexacaftor; tezacaftor; ivacaftor: (Moderate) Increased monitoring is recommended if ivacaftor is administered concurrently with CYP2C9 substrates, such as losartan. Ivacaftor is an inhibitor

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Android (methyltestosterone) dose, indications, adverse

Details: Monitor blood glucose and HbA1C when these drugs are used together. Sitagliptin: (Moderate) Changes in insulin sensitivity or glycemic control may occur in patients treated with androgens. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may decrease antidiabetic agent dosage requirements.

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Oxacillin (oxacillin) dose, indications, adverse effects

Details: Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. Another review concurred with these data, but noted that individual patients have been

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Flavoxate Hydrochloride (flavoxate hydrochloride) dose

Details: Because many drugs are excreted in human milk, caution should be exercised when flavoxate is administered to breast-feeding women. The effects of flavoxate are similar to other anticholinergics; one potential effect of anticholinergic drugs is the reduction of milk production, particularly when lactation is being established.

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Bacitracin Ointment (bacitracin) dose, indications

Details: Drugs that decrease renal function may also increase concentrations of tenofovir. Renal impairment, which may include hypophosphatemia, has been reported with the use of tenofovir with a majority of the cases occurring in patients who have underlying systemic or renal disease or who are concurrently taking nephrotoxic agents.

› Verified 8 days ago

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Coartem (artemether/lumefantrine) dose, indications

Details: Drugs with a possible risk for QT prolongation and torsades de pointes (TdP) that should be avoided with artemether; lumefantrine include eribulin. If eribulin and another drug that prolongs the QT interval, such as artemether; lumefantrine must be coadministered, ECG monitoring is recommended; closely monitor the patient for QT interval

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Glipizide and Metformin Hydrochloride (glipizide/metformin

Details: Drugs that are eliminated by renal tubular secretion, such as emtricitabine, may decrease metformin elimination by competing for common renal tubular transport systems. Although such interactions remain theoretical, careful patient monitoring and dose adjustment of metformin and/or the interfering cationic drug are recommended.

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Adzenys XR-ODT (amphetamine) dose, indications, adverse

Details: Thiazide diuretics and related drugs like indapamide may increase urinary pH, acting as a urinary alkalinizer, thus reducing urinary excretion and increasing blood concentrations of the amphetamine. Co-administration of amphetamines and urinary alkalinizing agents should be avoided if possible. If needed, monitor for common amphetamine side

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Armour Thyroid (thyroid) dose, indications, adverse

Details: Amobarbital: (Minor) Hepatic enzyme-inducing drugs, including barbiturates, can increase the catabolism of thyroid hormones. Be alert for a decreased response to thyroid replacement agents with dosage adjustments, discontinuation or addition of barbiturates during thyroid hormone replacement therapy.

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Advil FDA Drug Safety Communication PDR.net

Details: The U.S. Food and Drug Administration (FDA) is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke. Based on our comprehensive review of new safety information, we are requiring updates to the drug labels of all prescription NSAIDs.

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Zebutal (acetaminophen/butalbital/caffeine) dose

Details: (Minor) Drugs that induce the hepatic isoenzymes CYP2E1 and CYP1A2, such as efavirenz, may potentially increase the risk for acetaminophen-induced hepatotoxicity via generation of a greater percentage of acetaminophen's hepatotoxic metabolite, NAPQI. Also, the analgesic activity of acetaminophen may be reduced.

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Amoxicillin and Clavulanate Potassium Powder Drug

Details: The Related Drug Information Index provides comprehensive access to all drug information related to a specific drug Types of content include full prescribing information, drug summaries, Full Prescribing Information Continuing Medication Education (Full PI CME), Medication Guides, Risk Evaluation and Mitigation Strategies (REMS Summaries), REMS Continuing Medication Education (REMS CME), and

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Fibricor (fenofibric acid) dose, indications, adverse

Details: Since these drugs are also highly protein-bound, it is possible that fenofibric acid displaces warfarin from protein-binding sites as a potential mechanism. Case reports of significant effects on warfarin exist for all fibrate drugs. Fenofibric acid is the active metabolite of fenofibrate. Three clinical case reports of fenofibrate and warfarin

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Namenda (memantine hydrochloride) dose, indications

Details: Drugs that are eliminated by renal tubular secretion (e.g., memantine) may decrease metformin elimination by competing for common renal tubular transport systems. It should be noted that in a pharmacokinetic study in which memantine and glyburide; metformin (Glucovance) were coadministered, the pharmacokinetics of memantine, metformin, or

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Famotidine Injection (famotidine) dose, indications

Details: Drugs that increase the gastric pH may cause the premature release of cysteamine from delayed-release capsules, leading to an increase in WBC cystine concentration. Dacomitinib: (Moderate) Administer dacomitinib at least 6 hours before or 10 hours after taking famotidine due to the risk of decreased plasma concentrations of dacomitinib which

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